Terpenes as possible drugs for the mitigation of arthritic symptoms – A systematic review

• Published in: Phytomedicine (Stuttgart) Vol. 57; pp. 137 - 147
• Main Authors: Carvalho, Alexandra M.S., Heimfarth, Luana, Santos, Klécia A., Guimarães, Adriana G., Picot, Laurent, Almeida, Jackson R.G.S., Quintans, Jullyana S.S., Quintans-Júnior, Lucindo J.
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01-04-2019; Elsevier
• Subjects: Chronic disease; Cytokines; Human health and pathology; Inflammation; Life Sciences; Medication; Natural products; Pain; Pharmaceutical sciences; Rheumatic diseases; Rhumatology and musculoskeletal system; MAPKAP2; MCP-1; RANKL; RANTES; OPG; MPO; MSUC; Pain; GRO/KC; p38MAPKsp38; (p)-MKK-3/6; KC; AIA; CIA; AA; Cytokines; NFκB; Chronic disease; DMM; Rheumatic diseases; MMP3; Inflammation; MMP9; GR-α; MSU; PPARγ; MMP13; Natural products; NE; RORγ; Foxp3; CFA; Chronic Disease
• ISSN: 0944-7113; 1618-095X
• DOI: 10.1016/j.phymed.2018.10.028

Arthritis is a syndrome associated with exacerbated inflammation, joint destruction and chronic pain and disability. Chronic treatment of arthritis is associated with several side effects and high abandonment. Therefore, there has been an ongoing search for alternative treatments to overcome these problems.
Natural products, which are already widely used for their biological, cosmetic and pharmacotechnic properties, are a possible source for new drugs. Terpenes, a large class of organic compounds produced mainly by plants and trees, are a promising natural product and have already been shown to be effective in treating chronic pain, particularly of an inflammatory origin.
This review identifies the main terpenes with anti-arthritic activity reported in the last 10 years. A survey was conducted between December 2017 and June 2018 in the PUBMED, SCOPUS and Science Direct databases using combinations of the descriptors terpenes, arthritis and inflammation.
The results showed that terpenes have promising biological effects in relation to the treatment of arthritis, with the 24 terpenes identified in our survey being effective in the modulation of inflammatory mediators important to the physiopathology of arthritis, such as IL-6, IL-17, TNF-α, NFκB, and COX-2, among others. It is important to note that most of the studies used animal models, which limits, at least in part, the direct translation to humans of the experimental evidence produced by the studies.
Together, our finds suggest that terpenes can modulate the immuno-regulatory and destructive tissue events that underlie the clinical presentation and the progression of arthritis and are worthy of further clinical investigation.
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