Vascular homeostasis in atherosclerosis: A holistic overview

Vascular homeostasis in atherosclerosis: A holistic overview

Atherosclerosis refers to the deposition of lipids and the co-existence of inflammation and impaired inflammation resolution in pan-vasculature, which causes lumen narrowing, hardening, plaque formation, and the manifestation of acute cardiovascular events. Emerging evidence has suggested that vascu...

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Bibliographic Details
Published in:Frontiers in immunology Vol. 13; p. 976722
Main Authors: Xu, Suowen, Lyu, Qing Rex, Ilyas, Iqra, Tian, Xiao-Yu, Weng, Jianping
Format: Journal Article
Language:English
Published: Frontiers Media S.A 12-09-2022
Subjects:
aorta zonation
atherosclerosis
endothelial function
homeostasis
Immunology
vascular ecosystem
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Summary:Atherosclerosis refers to the deposition of lipids and the co-existence of inflammation and impaired inflammation resolution in pan-vasculature, which causes lumen narrowing, hardening, plaque formation, and the manifestation of acute cardiovascular events. Emerging evidence has suggested that vascular circulation can be viewed as a complex homeostatic system analogous to a mini-ecosystem which consists of the vascular microenvironment (niche) and the crosstalk among phenotypically and functionally diverse vascular cell types. Here, we elucidate how cell components in the vascular wall affect vascular homeostasis, structure, function, and atherosclerosis in a holistic perspective. Finally, we discuss the potential role of vascular-stabilizing strategies including pharmacotherapies, natural substances and lifestyle modifications, in preventing cardiovascular diseases by preserving vascular integrity and homeostasis.
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Reviewed by: Jian Xu, University of Oklahoma Health Sciences Center, United States; Yifan Lu, Temple University, United States
These authors have contributed equally to this work
This article was submitted to Molecular Innate Immunity, a section of the journal Frontiers in Immunology
ORCID: Suowen Xu, orcid.org/0000-0002-5488-5217, Jianping Weng orcid.org/0000-0002-7889-1697, Xiao-Yu Tian orcid.org/0000-0003-3472-9898
Edited by: Xiaofeng Yang, Temple University, United States
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.976722