Ultra-high-resolution fMRI of Human Ventral Temporal Cortex Reveals Differential Representation of Categories and Domains

• Published in: The Journal of neuroscience Vol. 40; no. 15; pp. 3008 - 3024
• Main Authors: Margalit, Eshed, Jamison, Keith W, Weiner, Kevin S, Vizioli, Luca, Zhang, Ru-Yuan, Kay, Kendrick N, Grill-Spector, Kalanit
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 08-04-2020
• Subjects: Categories; Corridors; Cortex (temporal); Domains; Functional magnetic resonance imaging; High resolution; Housing; Primates; Representations; Residential areas; Spatial resolution; Visual cortex; cortical depth; ventral temporal cortex; high-level visual cortex; visual categories; visual representations
• ISSN: 0270-6474; 1529-2401
• DOI: 10.1523/JNEUROSCI.2106-19.2020

Human ventral temporal cortex (VTC) is critical for visual recognition. It is thought that this ability is supported by large-scale patterns of activity across VTC that contain information about visual categories. However, it is unknown how category representations in VTC are organized at the submillimeter scale and across cortical depths. To fill this gap in knowledge, we measured BOLD responses in medial and lateral VTC to images spanning 10 categories from five domains (written characters, bodies, faces, places, and objects) at an ultra-high spatial resolution of 0.8 mm using 7 Tesla fMRI in both male and female participants. Representations in lateral VTC were organized most strongly at the general level of domains (e.g., places), whereas medial VTC was also organized at the level of specific categories (e.g., corridors and houses within the domain of places). In both lateral and medial VTC, domain-level and category-level structure decreased with cortical depth, and downsampling our data to standard resolution (2.4 mm) did not reverse differences in representations between lateral and medial VTC. The functional diversity of representations across VTC partitions may allow downstream regions to read out information in a flexible manner according to task demands. These results bridge an important gap between electrophysiological recordings in single neurons at the micron scale in nonhuman primates and standard-resolution fMRI in humans by elucidating distributed responses at the submillimeter scale with ultra-high-resolution fMRI in humans.
Visual recognition is a fundamental ability supported by human ventral temporal cortex (VTC). However, the nature of fine-scale, submillimeter distributed representations in VTC is unknown. Using ultra-high-resolution fMRI of human VTC, we found differential distributed visual representations across lateral and medial VTC. Domain representations (e.g., faces, bodies, places, characters) were most salient in lateral VTC, whereas category representations (e.g., corridors/houses within the domain of places) were equally salient in medial VTC. These results bridge an important gap between electrophysiological recordings in single neurons at a micron scale and fMRI measurements at a millimeter scale.