Influence of HLA gene polymorphisms on susceptibility and outcome post infection with the SARS-CoV virus

• Published in: Virologica Sinica Vol. 29; no. 2; pp. 128 - 130
• Main Authors: Yuan, Fang Fang, Velickovic, Zlatibor, Ashton, Lesley J., Dyer, Wayne B., Geczy, Andrew F., Dunckley, Heather, Lynch, Garry W., Sullivan, John S.
• Format: Journal Article
• Language: English
• Published: Heidelberg Wuhan Institute of Virology, CAS 01-04-2014; KeAi Publishing Communications Ltd; Veterinary Science, University of Sydney, NSW 2006, Australia; Australian Red Cross Blood Service, 17 O'Riordan St, Alexandria, NSW 2015, Australia%Central Clinical School, Sydney Medical School, University of Sydney, NSW 2006, Australia; Central Clinical School, Sydney Medical School, University of Sydney, NSW 2006, Australia%Central Clinical School, Sydney Medical School, University of Sydney, NSW 2006, Australia; Department of Cell & Molecular Therapies, Royal Prince Alfred Hospital, NSW 2050, Australia%Faculty of Medicine, University of New South Wales, High St,Kensington, NSW 2052, Australia%Central Clinical School, Sydney Medical School, University of Sydney, NSW 2006, Australia
• Subjects: Biochemistry; Biomedical and Life Sciences; Biomedicine; Cohort Studies; Disease Susceptibility; Histocompatibility antigen HLA; HLA; HLA Antigens - genetics; HLA Antigens - immunology; Humans; Letter; Medical Microbiology; Microbial Genetics and Genomics; Microbiology; Oncology; Polymorphism, Genetic; SARS Virus - immunology; SARS-CoV; SARS冠状病毒; Severe Acute Respiratory Syndrome - genetics; Severe Acute Respiratory Syndrome - immunology; Virology; 人类白细胞抗原; 呼吸系统综合症; 基因多态性; 感染; 敏感性; Severe Acute Respiratory Syndrome; Human Leukocyte Antigen; Human Leukocyte Antigen Allele; VIROLOGICA SINICA
• ISSN: 1674-0769; 1995-820X
• DOI: 10.1007/s12250-014-3398-x

Dear Editor,Severe Acute Respiratory Syndrome （SARS） has been described as the first pandemic of the 21 st century and between November 2002 and July 2003,over 8000 people were infected with the SARS-associated coronavirus （SARS-CoV）.Polymorphisms in the human leukocyte antigen （HLA） system have been shown to influence susceptibility to SARS-CoV but here we were unable to demonstrate any association between HLA and susceptibility or outcome post infection with the SARS-CoV.