Diorygmones A-B, two new guaiane-sesquiterpenes from the cultured lichen mycobiont of Diorygma sp

• Published in: Natural product research Vol. 38; no. 13; pp. 2282 - 2287
• Main Authors: Nguyen, Huu-Hung, Aree, Thammarat, Nguyen, Huy Truong, Tran, Thi-Minh-Dinh, Nguyen, Thi-Phuong, Vo, Thi-Phi Giao, Nguyen, Ngoc-Hong, Duong, Thuc-Huy
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 02-07-2024; Taylor & Francis Ltd
• Subjects: Circular Dichroism; Cultured lichen mycobiont; Cytotoxicity; Dichroism; Diorygma pruinosum; diorygmone; guaiane; Hep G2 Cells; Humans; Lichens; Lichens - chemistry; Lichens - microbiology; Magnetic Resonance Spectroscopy; Mass spectroscopy; Molecular Structure; NMR; Nuclear magnetic resonance; Sesquiterpenes; Sesquiterpenes, Guaiane - chemistry; Sesquiterpenes, Guaiane - pharmacology; Two dimensional analysis; Vietnam; Vietnam; guaiane; Diorygma pruinosum; diorygmone; Cultured lichen mycobiont
• ISSN: 1478-6419; 1478-6427; 1478-6427
• DOI: 10.1080/14786419.2023.2172007

Diorygma sp. is a native crustose-lichen in Vietnam. A mycobiont of this lichen was isolated, then cultivated. The present study described the isolation and structural elucidation of two new guaiane-type sesquiterpenes, namely diorygmones A-B. Their absolute chemical structures were elucidated by extensive 1D and 2D NMR analysis, high-resolution mass spectroscopy, electronic circular dichroism (ECD), and comparisons with the literatures. Compounds 1 and 2 were evaluated for cytotoxic activity against HepG2 cell line.