Bactericidal/permeability-increasing protein inhibits growth of a strain of Acholeplasma laidlawii and L forms of the Gram-positive bacteria Staphylococcus aureus and Streptococcus pyogenes

Bactericidal/permeability-increasing protein inhibits growth of a strain of Acholeplasma laidlawii and L forms of the Gram-positive bacteria Staphylococcus aureus and Streptococcus pyogenes

Bactericidal/permeability-increasing protein (BPI) inhibited growth of cell wall-deficient Acholeplasma laidlawii and L forms of certain strains of Staphylococcus aureus and Streptococcus pyogenes. However, the same strains of S. aureus and S. pyogenes with intact cell walls were not susceptible to...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy Vol. 43; no. 9; pp. 2314 - 2316
Main Authors: HORWITZ, A. H, WILLIAMS, R. E, LIU, P.-S, NADELL, R
Format: Journal Article
Language:English
Published: Washington, DC American Society for Microbiology 01-09-1999
Series:Note
Subjects:
Acholeplasma laidlawii
Acholeplasma laidlawii - drug effects
Acholeplasma laidlawii - growth & development
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimicrobial Cationic Peptides
Biological and medical sciences
Blood Proteins - pharmacology
Mechanisms of Action: Physiological Effects
Medical sciences
Membrane Proteins
Pharmacology. Drug treatments
Staphylococcus aureus
Staphylococcus aureus - classification
Staphylococcus aureus - drug effects
Staphylococcus aureus - growth & development
Streptococcus pyogenes
Streptococcus pyogenes - classification
Streptococcus pyogenes - drug effects
Streptococcus pyogenes - growth & development
Microorganism growth
Acholeplasmataceae
Permeability
In vitro
Biological activity
Protein
Bactericidal effect
Mollicutes
Streptococcaceae
Acholeplasmatales
Acholeplasma laidlawii
Bacteria
Micrococcales
Streptococcus pyogenes
Micrococcaceae
Antibacterial agent
Staphylococcus aureus
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Summary:Bactericidal/permeability-increasing protein (BPI) inhibited growth of cell wall-deficient Acholeplasma laidlawii and L forms of certain strains of Staphylococcus aureus and Streptococcus pyogenes. However, the same strains of S. aureus and S. pyogenes with intact cell walls were not susceptible to the growth-inhibitory effects of BPI.
Bibliography:ObjectType-Article-2
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Corresponding author. Mailing address: XOMA (U.S.) LLC, 1545 17th St., Santa Monica, CA 90404. Phone: (310) 829-7681. Fax: (310) 828-2463. E-mail: horwitz@xoma.com.
ISSN:0066-4804
1098-6596
DOI:10.1128/aac.43.9.2314