Involvement of the L-DOPA receptor GPR143 in acute and chronic actions of methylphenidate

• Published in: Journal of pharmacological sciences Vol. 152; no. 3; pp. 178 - 181
• Main Authors: Uchimura, Hiraku, Kanai, Kaori, Arai, Masami, Inoue, Miyu, Hishimoto, Akitoyo, Masukawa, Daiki, Goshima, Yoshio
• Format: Journal Article
• Language: English
• Published: Japan Elsevier B.V 01-07-2023; Elsevier
• Subjects: GPR143; L-DOPA; Methylphenidate; GPR143; Methylphenidate; L-DOPA
• ISSN: 1347-8613; 1347-8648
• DOI: 10.1016/j.jphs.2023.04.006

Methylphenidate (MPH) and methamphetamine (METH) are the current treatments of choice for attention deficit/hyperactivity disorder. We previously reported that METH induces the release of dopamine (DA) and of the neurotransmitter candidate L-3,4-dihydroxyphenylalanine (L-DOPA). In contrast, we here found that MPH increased the DA release while it did not affect the L-DOPA release from the dorsolateral striatum. Nevertheless, MPH-induced hyperlocomotion was reduced in Gpr143 (L-DOPA receptor) gene-deficient (Gpr143−/y) mice. The rewarding effect and increased c-fos expression induced by MPH were also attenuated in Gpr143−/y mice. Together, these findings suggest that GPR143 is involved in the acute and chronic actions of MPH.