Chordin cleavage is sizzling

Bone Morphogenetic Protein (Bmp) signalling has a critical function in patterning vertebrate and invertebrate embryos. A key regulator of Bmp signalling is Chordin, which binds Bmps and prevents them from interacting with their receptors. Two new papers identify the Frizzled-related protein Sizzled...

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Bibliographic Details
Published in:	Nature cell biology Vol. 8; no. 4; pp. 305 - 307
Main Authors:	Kimelman, David, Szeto, Daniel P
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01-04-2006
Subjects:	Animals Body Patterning - physiology Bone morphogenetic proteins Bone Morphogenetic Proteins - antagonists & inhibitors Bone Morphogenetic Proteins - metabolism Cell Polarity Cellular signal transduction Embryo Embryos Genetic aspects Glycoproteins - antagonists & inhibitors Glycoproteins - metabolism Intercellular Signaling Peptides and Proteins - metabolism Invertebrates Metalloproteases - antagonists & inhibitors Metalloproteases - metabolism Morphogenesis - genetics Physiological aspects Tolloid-Like Metalloproteinases Vertebrates Zebrafish Zebrafish Proteins - physiology United States
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Summary:	Bone Morphogenetic Protein (Bmp) signalling has a critical function in patterning vertebrate and invertebrate embryos. A key regulator of Bmp signalling is Chordin, which binds Bmps and prevents them from interacting with their receptors. Two new papers identify the Frizzled-related protein Sizzled as an unexpected regulator of Chordin stability.
Bibliography:	SourceType-Other Sources-1 ObjectType-News-1 ObjectType-Commentary-2 content type line 66
ISSN:	1465-7392 1476-4679
DOI:	10.1038/ncb0406-305