Release and transportation of Hedgehog molecules
Highlights ► Lipidated Hedgehog proteins spread in the hydrophilic extracellular space. ► Different Hedgehog carriers are involved in short and long range transportation. ► Carriers for Hedgehog work in parallel in the same cells.
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| Published in: | Current opinion in cell biology Vol. 24; no. 2; pp. 173 - 180 |
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| Format: | Journal Article |
| Language: | English |
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01-04-2012
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| Abstract | Highlights ► Lipidated Hedgehog proteins spread in the hydrophilic extracellular space. ► Different Hedgehog carriers are involved in short and long range transportation. ► Carriers for Hedgehog work in parallel in the same cells. |
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| AbstractList | Secretion of the Hedgehog morphogen induces different cell fates over the short and long ranges during developmental patterning. Mature Hedgehog carries hydrophobic palmitic acid and cholesterol modifications essential for its correct spread. The long-range activity of Hedgehog raises questions about how a dually lipidated protein can spread in the hydrophilic environment of the extracellular space. There is compelling experimental evidence in favour of the existence of several different carriers for Hedgehog transportation, via very different routes. This suggests that different accessory proteins and cellular machineries may be involved in the specific release of Hedgehog. I suggest that Hh carriers may work in parallel within a given cell and that developmental context may condition the choice of Hh carrier in secreting cells. Highlights ► Lipidated Hedgehog proteins spread in the hydrophilic extracellular space. ► Different Hedgehog carriers are involved in short and long range transportation. ► Carriers for Hedgehog work in parallel in the same cells. ► Lipidated Hedgehog proteins spread in the hydrophilic extracellular space. ► Different Hedgehog carriers are involved in short and long range transportation. ► Carriers for Hedgehog work in parallel in the same cells. Secretion of the Hedgehog morphogen induces different cell fates over the short and long ranges during developmental patterning. Mature Hedgehog carries hydrophobic palmitic acid and cholesterol modifications essential for its correct spread. The long-range activity of Hedgehog raises questions about how a dually lipidated protein can spread in the hydrophilic environment of the extracellular space. There is compelling experimental evidence in favour of the existence of several different carriers for Hedgehog transportation, via very different routes. This suggests that different accessory proteins and cellular machineries may be involved in the specific release of Hedgehog. I suggest that Hh carriers may work in parallel within a given cell and that developmental context may condition the choice of Hh carrier in secreting cells. |
| Author | Thérond, Pascal P |
| Author_xml | – sequence: 1 fullname: Thérond, Pascal P |
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| Snippet | Highlights ► Lipidated Hedgehog proteins spread in the hydrophilic extracellular space. ► Different Hedgehog carriers are involved in short and long range... ► Lipidated Hedgehog proteins spread in the hydrophilic extracellular space. ► Different Hedgehog carriers are involved in short and long range transportation.... Secretion of the Hedgehog morphogen induces different cell fates over the short and long ranges during developmental patterning. Mature Hedgehog carries... |
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| SubjectTerms | Animals Carrier Proteins Carrier Proteins - isolation & purification Cell Membrane Cell Membrane - metabolism Cholesterol Cholesterol - metabolism Development Biology Extracellular Space Extracellular Space - chemistry Extracellular Space - metabolism Hedgehog Proteins Hedgehog Proteins - metabolism Internal Medicine Life Sciences Morphogenesis Palmitic Acid Palmitic Acid - metabolism Protein Processing, Post-Translational Protein Transport |
| Title | Release and transportation of Hedgehog molecules |
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