Effect of L-arginine on in vitro plasmin-generation and fibrinogenolysis

• Published in: Thrombosis research Vol. 87; no. 1; pp. 75 - 82
• Main Authors: Udvardy, M, Posán, E, Palatka, K, Altorjay, I, Harsfalvi, J
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Ltd 01-07-1997; Elsevier Science
• Subjects: Arginine - metabolism; Arginine - pharmacology; Biological and medical sciences; Blood coagulation. Blood cells; clot lysis; Fibrinogen - metabolism; fibrinogenolysis; Fibrinolysin - metabolism; fibrinolysis; Fundamental and applied biological sciences. Psychology; General aspects, investigation methods, hemostasis, fibrinolysis; Humans; Kinetics; L-arginine; Molecular and cellular biology; fibrinolysis; fibrinogenolysis; L-arginine; clot lysis; Human; L-aminoacid; Arginine; Clot retraction; Fibrinolysis; In vitro
• ISSN: 0049-3848; 1879-2472
• DOI: 10.1016/S0049-3848(97)00106-0

L-arginine has received much attention in numerous aspects of the regulation of vascular tone and haemostasis. L-arginine seems to be capable to bind to plasminogen, too. The aim of the present paper is to investigate the action of L-arginine on in vitro plasmin generation and fibrino(geno)lysis by chromogenic, kinetic plasmin generation assay and electrophoretic analysis. The acceleration of tPA-induced plasmin generation in the presence of low concentration of L-arginine, along with augmentation of in vitro fibrinogenolysis have been documented. L-arginine may have a role in the modification of fibrinogenolysis, and this role should be considered if arginine is used as an element of some novel antithrombotic agents. © 1997 Elsevier Science Ltd