Effects of ciguatoxin and maitotoxin on isolated rat atria and rabbit duodenum

Ciguatoxin and maitotoxin, extracted from a species of moray-eel, Gymnothorax javanicus, and from a wild dinoflagellate, Gambierdiscus toxicus, were tested on rat atria and rabbit duodenum. Biphasic inotropic and chronotropic responses with excitatory and inhibitory components were observed. The eff...

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Bibliographic Details
Published in:	Toxicon (Oxford) Vol. 22; no. 3; p. 471
Main Authors:	Legrand, A M, Bagnis, R
Format:	Journal Article
Language:	English
Published:	England 1984
Subjects:	Animals Atropine - pharmacology Ciguatoxins - pharmacology Duodenum - drug effects Guinea Pigs Heart - drug effects Heart Rate - drug effects In Vitro Techniques Marine Toxins - pharmacology Muscle Contraction - drug effects Muscle, Smooth - drug effects Myocardial Contraction - drug effects Oxocins Rabbits Rats Receptors, Muscarinic - drug effects
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Summary:	Ciguatoxin and maitotoxin, extracted from a species of moray-eel, Gymnothorax javanicus, and from a wild dinoflagellate, Gambierdiscus toxicus, were tested on rat atria and rabbit duodenum. Biphasic inotropic and chronotropic responses with excitatory and inhibitory components were observed. The effects of agents such as reserpine, propranolol, phentolamine, atropine and manganese ions were investigated. We conclude that, at the dosage levels used, ciguatoxin acts mainly at the nerve endings, while maitotoxin exerts prominent toxic effects on muscles.
ISSN:	0041-0101
DOI:	10.1016/0041-0101(84)90091-6