Toll-like receptor expression and function in type I bipolar disorder

• Published in: Brain, behavior, and immunity Vol. 54; pp. 110 - 121
• Main Authors: Wieck, Andrea, Grassi-Oliveira, Rodrigo, do Prado, Carine Hartmann, Viola, Thiago Wendt, Petersen, Laura Esteves, Porto, Bárbara, Teixeira, Antônio Lúcio, Bauer, Moisés Evandro
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01-05-2016
• Subjects: Adult; Allergy and Immunology; Bipolar disorder; Bipolar Disorder - genetics; Bipolar Disorder - immunology; Bipolar Disorder - metabolism; Case-Control Studies; Cytokines - metabolism; Female; Flow Cytometry; Gene Expression; Humans; Immunity, Innate; Immunophenotyping - methods; Inflammation; Innate immunity; Interleukins - metabolism; Lipopolysaccharides - immunology; Middle Aged; Monocytes; Monocytes - metabolism; Psychiatry; Regulatory T cells; Signal Transduction; Toll-like receptors; Toll-Like Receptors - biosynthesis; Toll-Like Receptors - genetics; Toll-Like Receptors - immunology; Toll-Like Receptors - metabolism; Tumor Necrosis Factor-alpha - metabolism; Toll-like receptors; Bipolar disorder; Innate immunity; Monocytes; Inflammation; Regulatory T cells
• ISSN: 0889-1591; 1090-2139
• DOI: 10.1016/j.bbi.2016.01.011

Highlights • BD subjects have differential distribution and functioning of TLR1/2 monocytes. • Cells of BD subjects secrete more IL-1β and IL12-p70 in response to TLR1/2 agonists. • BD patients had increased percentages of TLR2+ and TLR5+ T cells (incl. Treg). • Impaired TLR signaling may contribute to the inflammation profile observed in BD. • TLR alterations were negatively correlated to years of disease in BD subjects.