Expression of platelet-derived growth factor-BB in liver tissues of patients with chronic hepatitis B

AIM:To study the relationship between expression of plateletderived growth factor-BB (PDGF-BB) and fibrogenesis in chronic hepatitis B.METHODS:Hepatic tissues from 43 patients with chronic hepatitis B were embedded in paraffin.The sections were stained with HE and picric acid-sirius red to determine...

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Published in:	World journal of gastroenterology : WJG Vol. 10; no. 3; pp. 385 - 388
Main Authors:	Lou, Song-Mei, Li, You-Ming, Wang, Kai-Ming, Cai, Wei-Min, Weng, Hong-Lei
Format:	Journal Article
Language:	English
Published:	United States Department of Gastroenterology, Hangzhou First People's Hospital, Hangzhou 310006, Zhejiang Province, China%First Affiliated Hospital, College of Medicine, Zhejiang Univereity,Hangzhou 310003, Zhejiang Province, China 01-02-2004 Baishideng Publishing Group Inc
Subjects:	Becaplermin Biopsy Hepatitis B, Chronic - metabolism Hepatitis B, Chronic - pathology Humans Liver - metabolism Liver - pathology Liver Cirrhosis - blood Platelet-Derived Growth Factor - metabolism Proto-Oncogene Proteins c-sis Viral Hepatitis 慢性乙型肝炎肝纤维化肝组织血小板源性生长因子-BB 血清学检查
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Abstract	AIM:To study the relationship between expression of plateletderived growth factor-BB (PDGF-BB) and fibrogenesis in chronic hepatitis B.METHODS:Hepatic tissues from 43 patients with chronic hepatitis B were embedded in paraffin.The sections were stained with HE and picric acid-sirius red to determine inflammatory activity and fibrosis stages. PDGF-BB expression was detected by immunohistochemistry and assessed semiquantatively. Levels of serum hyaluronic acid (HA),pro-collagen Ⅲ(PCⅢ), collagen Ⅳ (Ⅳ-C) and laminin (LN) were examined by radioimmunoassay (RIA).RESULTS:The expression level of PDGF-BB was found to be positively correlated with inflammatory activity, fibrosis stage and grade of histological findings (τ=0.58,0.55,0.55,P<0.01).The positive correlation was also observed between tissue level of PDGF-BB expression and contents of HA, PCⅢ, Ⅳ-C and LN in the circulation (r=0.52,0.32,0.40,0.33, P<0.05).CONCLUSION: PDGF-BB may play some role in the development and progression of liver fibrosis.
AbstractList	R5; AIM: To study the relationship between expression of plateletderived growth factor-BB (PDGF-BB) and fibrogenesis in chronic hepatitis B.METHODS: Hepatic tissues from 43 patients with chronic hepatitis B were embedded in paraffin. The sections were stained with HE and picric acid-sirius red to determine inflammatory activity and fibrosis stages. PDGF-BB expression was detected by immunohistochemistry and assessed semiquantatively. Levels of serum hyaluronic acid (HA),pro-collagen Ⅲ (PCⅢ), collagen Ⅳ (Ⅳ-C) and laminin (LN)were examined by radioimmunoassay (RIA).RESULTS: The expression level of PDGF-BB was found to be positively correlated with inflammatory activity, fibrosis stage and grade of histological findings (τ=0.58, 0.55,0.55, P＜0.01). The positive correlation was also observed between tissue level of PDGF-BB expression and contents Of HA, PCⅢ, Ⅳ-C and LN in the circulation (r=0.52, 0.32,0.40, 0.33, P＜0.05).CONCLUSION: PDGF-BB may play some role in the development and progression of liver fibrosis. AIM: To study the relationship between expression of platelet-derived growth factor-BB (PDGF-BB) and fibrogenesis in chronic hepatitis B. METHODS: Hepatic tissues from 43 patients with chronic hepatitis B were embedded in paraffin. The sections were stained with HE and picric acid-sirius red to determine inflammatory activity and fibrosis stages. PDGF-BB expression was detected by immunohistochemistry and assessed semiquantatively. Levels of serum hyaluronic acid (HA), pro-collagen III (PCIII), collagen IV (IV-C) and laminin (LN) were examined by radioimmunoassay (RIA). RESULTS: The expression level of PDGF-BB was found to be positively correlated with inflammatory activity, fibrosis stage and grade of histological findings (τ = 0.58, 0.55, 0.55, P < 0.01). The positive correlation was also observed between tissue level of PDGF-BB expression and contents of HA, PCIII, IV-C and LN in the circulation ( r = 0.52, 0.32, 0.40, 0.33, P < 0.05). CONCLUSION: PDGF-BB may play some role in the development and progression of liver fibrosis. AIM:To study the relationship between expression of plateletderived growth factor-BB (PDGF-BB) and fibrogenesis in chronic hepatitis B.METHODS:Hepatic tissues from 43 patients with chronic hepatitis B were embedded in paraffin.The sections were stained with HE and picric acid-sirius red to determine inflammatory activity and fibrosis stages. PDGF-BB expression was detected by immunohistochemistry and assessed semiquantatively. Levels of serum hyaluronic acid (HA),pro-collagen Ⅲ(PCⅢ), collagen Ⅳ (Ⅳ-C) and laminin (LN) were examined by radioimmunoassay (RIA).RESULTS:The expression level of PDGF-BB was found to be positively correlated with inflammatory activity, fibrosis stage and grade of histological findings (τ=0.58,0.55,0.55,P<0.01).The positive correlation was also observed between tissue level of PDGF-BB expression and contents of HA, PCⅢ, Ⅳ-C and LN in the circulation (r=0.52,0.32,0.40,0.33, P<0.05).CONCLUSION: PDGF-BB may play some role in the development and progression of liver fibrosis. AIMTo study the relationship between expression of platelet-derived growth factor-BB (PDGF-BB) and fibrogenesis in chronic hepatitis B.METHODSHepatic tissues from 43 patients with chronic hepatitis B were embedded in paraffin. The sections were stained with HE and picric acid-sirius red to determine inflammatory activity and fibrosis stages. PDGF-BB expression was detected by immunohistochemistry and assessed semiquantatively. Levels of serum hyaluronic acid (HA), pro-collagen III (PCIII), collagen IV (IV-C) and laminin (LN) were examined by radioimmunoassay (RIA).RESULTSThe expression level of PDGF-BB was found to be positively correlated with inflammatory activity, fibrosis stage and grade of histological findings (tau=0.58, 0.55, 0.55, P<0.01). The positive correlation was also observed between tissue level of PDGF-BB expression and contents of HA, PCIII, IV-C and LN in the circulation (r=0.52, 0.32, 0.40, 0.33, P<0.05).CONCLUSIONPDGF-BB may play some role in the development and progression of liver fibrosis. To study the relationship between expression of platelet-derived growth factor-BB (PDGF-BB) and fibrogenesis in chronic hepatitis B. Hepatic tissues from 43 patients with chronic hepatitis B were embedded in paraffin. The sections were stained with HE and picric acid-sirius red to determine inflammatory activity and fibrosis stages. PDGF-BB expression was detected by immunohistochemistry and assessed semiquantatively. Levels of serum hyaluronic acid (HA), pro-collagen III (PCIII), collagen IV (IV-C) and laminin (LN) were examined by radioimmunoassay (RIA). The expression level of PDGF-BB was found to be positively correlated with inflammatory activity, fibrosis stage and grade of histological findings (tau=0.58, 0.55, 0.55, P<0.01). The positive correlation was also observed between tissue level of PDGF-BB expression and contents of HA, PCIII, IV-C and LN in the circulation (r=0.52, 0.32, 0.40, 0.33, P<0.05). PDGF-BB may play some role in the development and progression of liver fibrosis.
Author	Song-MeiLou You-MingLi Kai-MingWang Wei-Mincai Hong-LeiWeng
AuthorAffiliation	DepartmentofGastroenterology,HangzhouFirstPeople＇sHospital,Hangzhou310006,ZhejiangProvince,China FirstAffiliatedHospital,CollegeofMedicine,ZhejiangUniversity,Hangzhou310003,ZhejiangProvince,China
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Cites_doi	10.1016/S0168-8278(97)80184-5 10.1111/1523-1747.ep12276895 10.1002/hep.1840110322 10.1152/ajpcell.1991.260.3.C485 10.1172/JCI114363 10.1002/hep.1840200420 10.1016/0092-8674(86)90733-6 10.1097/00000478-199512000-00007 10.1126/science.2343305 10.1002/hep.1840190629 10.1172/JCI114362 10.1016/S0021-9258(18)81860-9 10.1172/JCI114886 10.1152/ajpgi.1993.264.4.G589 10.1172/JCI113671 10.1055/s-2008-1040454 10.1152/ajpcell.1992.262.4.C876 10.1096/fasebj.5.3.2001786 10.1055/s-2008-1040452 10.1055/s-2008-1040455 10.1002/path.1711700203 10.1016/S0021-9258(18)31541-2 10.1172/JCI114669 10.1002/hep.1840080508 10.1038/ki.1991.234
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Notes	14-1219/R R446.11 R512.62 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Correspondence to: Song-Mei Lou, Department of Gastroenterology, Hangzhou First People’s Hospital, Hangzhou 310006, Zhejiang Province, China. lousm_72@hotmail.com Telephone: +86-571-87065701-2184 Author contributions: All authors contributed equally to the work.
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Snippet	AIM:To study the relationship between expression of plateletderived growth factor-BB (PDGF-BB) and fibrogenesis in chronic hepatitis B.METHODS:Hepatic tissues... To study the relationship between expression of platelet-derived growth factor-BB (PDGF-BB) and fibrogenesis in chronic hepatitis B. Hepatic tissues from 43... AIMTo study the relationship between expression of platelet-derived growth factor-BB (PDGF-BB) and fibrogenesis in chronic hepatitis B.METHODSHepatic tissues... R5; AIM: To study the relationship between expression of plateletderived growth factor-BB (PDGF-BB) and fibrogenesis in chronic hepatitis B.METHODS: Hepatic... AIM: To study the relationship between expression of platelet-derived growth factor-BB (PDGF-BB) and fibrogenesis in chronic hepatitis B. METHODS: Hepatic...
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SubjectTerms	Becaplermin Biopsy Hepatitis B, Chronic - metabolism Hepatitis B, Chronic - pathology Humans Liver - metabolism Liver - pathology Liver Cirrhosis - blood Platelet-Derived Growth Factor - metabolism Proto-Oncogene Proteins c-sis Viral Hepatitis 慢性乙型肝炎肝纤维化肝组织血小板源性生长因子-BB 血清学检查
Title	Expression of platelet-derived growth factor-BB in liver tissues of patients with chronic hepatitis B
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