The influence of ascorbic acid on lipid peroxidation in guinea pigs intoxicated with cadmium

• Published in: Food and chemical toxicology Vol. 30; no. 12; p. 1011
• Main Authors: Hudecová, A, Ginter, E
• Format: Journal Article
• Language: English
• Published: England 01-12-1992
• Subjects: Administration, Oral; Animals; Ascorbic Acid - therapeutic use; Cadmium - antagonists & inhibitors; Cadmium - toxicity; Cadmium Chloride; Cadmium Poisoning - metabolism; Cadmium Poisoning - prevention & control; Chlorides - antagonists & inhibitors; Chlorides - toxicity; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Guinea Pigs; Kidney - drug effects; Kidney - metabolism; Lipid Peroxidation - drug effects; Liver - drug effects; Liver - metabolism; Male; Malondialdehyde - blood; Malondialdehyde - metabolism
• ISSN: 0278-6915
• DOI: 10.1016/0278-6915(92)90111-W

Cadmium (as CdCl2) administered at a dose of 1 mg Cd/animal/day in drinking water to guinea pigs with a low intake of ascorbic acid (2 mg/animal/day) increased lipid peroxidation (LPO) in the kidney, liver and serum after 5 wk of treatment. A high intake of ascorbic acid (100 mg/animal/day) decreased LPO (determined from malondialdehyde levels) in the kidney, liver and serum of Cd-treated guinea pigs. Administration of Cd to guinea pigs with a low intake of ascorbic acid significantly increased LPO in the kidney at 5 wk, in comparison with controls given low levels of ascorbic acid but no Cd. However, at 12 wk, LPO in the kidney of Cd-treated guinea pigs was significantly lower than in the controls. These results indicate that the level of lipid peroxides in the kidney of guinea pigs with a low intake of ascorbic acid depends on the amount of accumulated cadmium.