Abnormalities of diaphragmatic muscle in neonates with ventilated lungs

Several infants and neonates who had received long-term ventilatory assistance had subnormal diaphragmatic muscle mass on gross necropsy examination. We conducted a retrospective study of our hospital infant necropsy files to determine whether prolonged ventilatory support was associated with diminu...

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Bibliographic Details
Published in:	The Journal of pediatrics Vol. 113; no. 6; p. 1074
Main Authors:	Knisely, A S, Leal, S M, Singer, D B
Format:	Journal Article
Language:	English
Published:	United States 01-12-1988
Subjects:	Diaphragm - pathology Humans Infant Infant, Newborn Long-Term Care Muscular Atrophy - pathology Respiration, Artificial Respiratory Distress Syndrome, Newborn - pathology Retrospective Studies
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Summary:	Several infants and neonates who had received long-term ventilatory assistance had subnormal diaphragmatic muscle mass on gross necropsy examination. We conducted a retrospective study of our hospital infant necropsy files to determine whether prolonged ventilatory support was associated with diminution in myofiber cross-sectional area selectively affecting the diaphragm. We found that long-term ventilatory assistance may predispose diaphragmatic myofibers to disuse atrophy or to failure or normal growth. This phenomenon may contribute to difficulties in weaning infants from ventilatory support.
ISSN:	0022-3476
DOI:	10.1016/S0022-3476(88)80585-7