Choroidal and Choriocapillaris Changes after Photodynamic Therapy and Subthreshold Micropulse Laser Treatment for Central Serous Chorioretinopathy

• Published in: Medicina (Kaunas, Lithuania) Vol. 60; no. 10; p. 1674
• Main Authors: Ruggeri, Maria Ludovica, Di Nicola, Marta, Passamonti, Marzia, Lorenzi, Carolina, Quarta, Alberto, Mastropasqua, Rodolfo, Toto, Lisa
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 12-10-2024; MDPI
• Subjects: Adult; Analysis; Biological markers; Cancer; Care and treatment; central serous chorioretinopathy; Central Serous Chorioretinopathy - drug therapy; Central Serous Chorioretinopathy - physiopathology; Central Serous Chorioretinopathy - surgery; choroid; Choroid - blood supply; Choroid - diagnostic imaging; Corticosteroids; Diagnosis; Disease; Dosage and administration; Female; Humans; Laser Therapy - methods; Lasers; Male; Medical imaging; Middle Aged; Morphology; optical coherence tomography; optical coherence tomography angiography; Pathogenesis; Patient outcomes; Photochemotherapy; Photochemotherapy - methods; Photodynamic Therapy; Retinal diseases; Subthreshold Micropulse Laser; Tomography; Tomography, Optical Coherence - methods; Treatment Outcome; Visual Acuity; Italy; United States > US; Germany; choroid; Subthreshold Micropulse Laser; Photodynamic Therapy; optical coherence tomography; central serous chorioretinopathy; optical coherence tomography angiography
• ISSN: 1648-9144; 1010-660X; 1648-9144
• DOI: 10.3390/medicina60101674

: The aim of the present study is to analyze choroidal and choriocapillaris structural and functional changes in eyes affected by Central serous chorioretinopathy after Photodynamic Therapy (PDT) and Subthreshold Micropulse laser (SML) treatment.
: Forty-two eyes of forty-two patients were analyzed in this observational study. Twenty-four patients underwent SML treatment, whereas eighteen patients were treated with PDT. Examinations were performed at baseline and after 3 months of treatment. Main outcome measures were: Best corrected visual acuity (BCVA), central macular thickness (CMT), central choroidal thickness (CCT), pigment epithelial detachment (PED) presence and maximum height (PEDMH), and choroidal vascularity index (CVI) measured by means of Spectralis HRA + OCT (Heidelberg Engineering, Heidelberg, Germany) Optical coherence tomography (OCT) and choriocapillaris flow voids (CCFV) measured on Optical Coherence Tomography Angiography (OCT-A) platform PLEX Elite 9000 device (Carl Zeiss Meditec Inc., Dublin, CA, USA).
: Changes in BCVA were registered in both groups over time (
< 0.001). Structural changes in terms of reduced CMT and PED presence were noted in the two groups at follow-up (
< 0.001 and
= 0.001, respectively). Structural and functional choroidal changes were found in the two groups with reduced CCT and CVI over time (
= 0.004 and
= 0.007, respectively), with significant differences between the two groups for CVI parameter (
= 0.001). CCFV increased over time in the PDT group and decreased in the SML group.
: PDT and SML are effective approaches in CSC eyes and are able to improve structural and functional parameters over time. Choroidal and choriocapillaris parameters are promising biomarkers able to monitor disease course, showing greater impact of PDT on choroid-choriocapillaris complex over time.