Clinical Implications of the Obese-Asthma Phenotypes

• Published in: Immunology and allergy clinics of North America Vol. 34; no. 4; pp. 739 - 751
• Main Authors: Diaz, Jennifer, MD, Farzan, Sherry, MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-11-2014
• Subjects: Adrenal Cortex Hormones - therapeutic use; Adult; Allergy and Immunology; Asthma; Asthma - diagnosis; Asthma - drug therapy; Asthma - epidemiology; Body mass index; Child; Depression - epidemiology; Diet; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Obesity; Obesity - diagnosis; Obesity - drug therapy; Obesity - epidemiology; Phenotype; Phenotypes; Prevalence; Sleep Apnea, Obstructive - epidemiology; Obesity; Body mass index; Phenotypes; Asthma
• ISSN: 0889-8561; 1557-8607
• DOI: 10.1016/j.iac.2014.07.008

The concomitant increase in obesity and asthma in recent years has led to the classification of two obese-asthma phenotypes, characterized by the age of asthma onset and atopy. Asthma tends to be more severe, harder to control, and more resistant to standard medications among members of these two groups. Because of the limited effectiveness of inhaled corticosteroids, dietary changes and weight loss measures must be considered in the management of these patients. Furthermore, comorbidities such as depression and obstructive sleep apnea must be addressed to provide optimal care for this group of difficult-to-control asthmatics.