Arterial spin labeling perfusion-weighted imaging aids in prediction of molecular biomarkers and survival in glioblastomas

• Published in: European radiology Vol. 30; no. 2; pp. 1202 - 1211
• Main Authors: Yoo, Roh-Eul, Yun, Tae Jin, Hwang, Inpyeong, Hong, Eun Kyoung, Kang, Koung Mi, Choi, Seung Hong, Park, Chul-Kee, Won, Jae-Kyung, Kim, Ji-hoon, Sohn, Chul-Ho
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-02-2020; Springer Nature B.V
• Subjects: Biomarkers; Biopsy; Blood flow; Cerebral blood flow; Chemoradiotherapy; Chemotherapy; Correlation analysis; Diagnostic Radiology; DNA methylation; DNA methyltransferase; Glioblastoma; Imaging; Internal Medicine; Interventional Radiology; Isocitrate dehydrogenase; Labeling; Medicine; Medicine & Public Health; Methylguanine; Mutation; Neuroradiology; O6-methylguanine-DNA methyltransferase; Oncology; Perfusion; Radiology; Spin labeling; Survival; Temozolomide; Ultrasound; Perfusion-weighted imaging; Overall survival; Isocitrate dehydrogenase; Progression-free survival; Glioblastoma
• ISSN: 0938-7994; 1432-1084
• DOI: 10.1007/s00330-019-06379-2

Objectives
Prediction of progression-free survival (PFS) and overall survival (OS) and early identification of molecular biomarkers with prognostic information are clinically important in glioblastoma (GBM) patients. We aimed to explore the utility of arterial spin labeling perfusion-weighted imaging (ASL-PWI) in the prediction of molecular biomarkers and survival in GBM patients.
Methods
We retrospectively analyzed 149 consecutive GBM patients, who had undergone maximal surgical resection or biopsy followed by concurrent chemoradiotherapy and adjuvant chemotherapy using temozolomide between November 2010 and June 2016. On preoperative ASL-PWI, cerebral blood flow (CBF) within contrast-enhancing (CE) and nonenhancing (NE) portions were evaluated both qualitatively (perfusion pattern
[CE]
and perfusion pattern
[NE]
) and quantitatively (nCBF
CE
and nCBF
NE
). ASL-PWI findings were correlated with molecular biomarkers, including isocitrate dehydrogenase (IDH) and
O
6-methylguanine-DNA methyltransferase (MGMT) methylation statuses, and survival, using the Mann-Whitney U-test, Spearman rank correlation, Kaplan-Meier analysis, and receiver operating characteristics analysis.
Results
nCBF
CE
was significantly higher in the IDH wild-type group than in the IDH mutant group (
p
 = .013) and in the MGMT unmethylated group than in the methylated group (
p
 = .047). Areas under the receiver operating characteristic curve were 0.678 for IDH mutation (
p
 = .022) and 0.601 for MGMT promoter methylation (
p
 = .043). Hyperperfusion was associated with the shortest median PFS for both perfusion pattern
[CE]
(7.6 months) and perfusion pattern
[NE]
(4.0 months). The perfusion pattern
[NE]
remained an independent predictor for PFS and OS even after adjusting for clinical and molecular predictors, unlike perfusion pattern
[CE]
.
Conclusions
ASL-PWI can aid to predict survival and molecular biomarkers including IDH mutation and MGMT promoter methylation statuses in GBM patients.
Key Points
• ASL-PWI can aid to predict survival in GBM patients.
• ASL-PWI can aid to predict IDH and MGMT promoter methylation statuses in GBM.