Photodynamic application of protoporphyrin IX as a photosensitizer encapsulated by silica nanoparticles

• Published in: Artificial cells, nanomedicine, and biotechnology Vol. 46; no. sup3; p. S1043
• Main Authors: Makhadmeh, Ghaseb N, Abdul Aziz, Azlan
• Format: Journal Article
• Language: English
• Published: England 01-01-2018
• Subjects: Bone Neoplasms - drug therapy; Bone Neoplasms - metabolism; Bone Neoplasms - pathology; Humans; Nanoparticles - therapeutic use; Osteosarcoma - drug therapy; Osteosarcoma - metabolism; Osteosarcoma - pathology; Photochemotherapy; Photosensitizing Agents - pharmacology; Protoporphyrins - pharmacology; Silicon Dioxide - therapeutic use; osteosarcoma cells; encapsulation; Photodynamic therapy; protoporphyrin IX; silica nanoparticles
• ISSN: 2169-141X
• DOI: 10.1080/21691401.2018.1528982

Achieved Silica Nanoparticles (SiNPs) to encapsulate the photosensitizer [Protoporphyrin IX (PpIX)] in photodynamic therapy (PDT) application was reported in this research.
Cytotoxicity for five different concentrations of encapsulated and naked PpIX was measured. Optimum concentration and optimum exposure time of encapsulated and naked PpIX that needed to destroy the cells (Osteosarcoma cells) was measured.
The results showed that the encapsulated PpIX has more efficacy compared to the naked PpIX and the applicability of the encapsulated PpIX-SiNPs was proved on osteosarcoma cells.
The results established the important in-vitro photodynamic effectiveness of PpIX-SiNP, which may open a new application for PpIX in its clinical and in-vitro studies.