The effects of environmental factors on the virulence of Trichomonas vaginalis

• Published in: Microbes and infection Vol. 14; no. 15; pp. 1411 - 1427
• Main Authors: Figueroa-Angulo, Elisa E., Rendón-Gandarilla, Francisco J., Puente-Rivera, Jonathan, Calla-Choque, Jaeson S., Cárdenas-Guerra, Rosa E., Ortega-López, Jaime, Quintas-Granados, Laura I., Alvarez-Sánchez, M. Elizbeth, Arroyo, Rossana
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01-12-2012
• Subjects: Cell contact; Female; Humans; Iron; Polyamines; Trichomonas vaginalis; Trichomonas vaginalis - metabolism; Trichomonas vaginalis - pathogenicity; Trichomonas Vaginitis - metabolism; Trichomonas Vaginitis - parasitology; Virulence; Virulence Factors - metabolism; Virulence Factors - physiology; Zinc; Trichomonas vaginalis; Cell contact; Iron; Polyamines; Virulence; Zinc
• ISSN: 1286-4579; 1769-714X
• DOI: 10.1016/j.micinf.2012.09.004

This review focused on potential regulatory mechanisms of Trichomonas vaginalis virulence properties, cytoadherence, cytotoxicity, phagocytosis, hemolysis, induction of apoptosis, and immune evasion in response to environmental factors of the human urogenital tract, iron, zinc, and polyamines. Understanding the multifactorial nature of trichomonal pathogenesis and its regulation may help to unravel the survival strategies of trichomonads and to implement prevention policies, opportune diagnosis, and alternative treatments for control of trichomoniasis.