B-cell lymphoblastic lymphoma in the maxilla of a child: A rare case report

• Published in: International journal of oral and maxillofacial surgery Vol. 38; no. 12; pp. 1326 - 1330
• Main Authors: Cavalcante, A.S.R, Anbinder, A.L, Pontes, E.M, Carvalho, Y.R
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01-12-2009; Elsevier
• Subjects: Antigens, CD20 - analysis; b-cell; Biological and medical sciences; Biomarkers, Tumor - analysis; Biopsy; CD79 Antigens - analysis; Child; children; Dentistry; DNA Nucleotidylexotransferase - analysis; Facial Asymmetry - diagnosis; Fatal Outcome; Female; Hematologic and hematopoietic diseases; Humans; Immunohistochemistry; immunophenotyping; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Leukocyte Common Antigens - analysis; lymphoma; Lymphoma, B-Cell - diagnosis; maxillary neoplasms; Maxillary Neoplasms - diagnosis; Medical sciences; Neprilysin - analysis; Otorhinolaryngology. Stomatology; Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis; Radiography, Panoramic; Surgery; Tomography, X-Ray Computed; immunophenotyping; children; b-cell; lymphoma; maxillary neoplasms; Human; Stomatology; Maxillary; Malignant hemopathy; Lymphoma; Case study; Treatment; Lymphoproliferative syndrome; Surgery; Tumor; β Cell; Child; Cancer
• ISSN: 0901-5027; 1399-0020
• DOI: 10.1016/j.ijom.2009.07.010

Abstract Lymphoblastic lymphoma is a malignant neoplasia that originates from B or T lymphocyte precursors and rarely occurs in the mouth. The authors report a rare case of B-cell lymphoblastic lymphoma in the maxilla of a child. Clinical examination revealed facial asymmetry with a swelling of the right maxilla, covered by healthy mucosa and painful to palpation. Radiographic examination revealed a poorly defined radiolucent lesion. Based on the hypothesis of malignant neoplasia of hematopoietic origin, an incisional biopsy was performed. Histological examination revealed malignant neoplasia with proliferation of monomorphic, lymphoid cells. Immunohistochemical staining was positive for leucocyte common antigen (LCA), CD10, CD20, CD79, and terminal deoxynucleotidyl transferase (TdT). After the diagnosis of B-cell lymphoblastic lymphoma, the patient underwent chemotherapy, but died of leukoencephalopathy and demyelinization caused by high doses of methotrexate.