Midgut neuroendocrine tumor presenting with acute intestinal ischemia

Midgut neuroendocrine tumor presenting with acute intestinal ischemia

Neuroendocrine tumors represent a heterogeneous group of neoplasms that arise from neuroendocrine cells and secrete various peptides and bioamines. While gastrointestinal neuroendocrine tumors,commonly called carcinoids,account for about 2/3 of all neuroendocrine tumors,they are relatively rare. Sma...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG Vol. 23; no. 45; pp. 8090 - 8096
Main Authors: Mantzoros, Ioannis, Savvala, Natalia Antigoni, Ioannidis, Orestis, Parpoudi, Styliani, Loutzidou, Lydia, Kyriakidou, Despoina, Cheva, Angeliki, Intzos, Vasileios, Tsalis, Konstantinos
Format: Journal Article
Language:English
Published: United States Baishideng Publishing Group Inc 07-12-2017
Subjects:
Case Report
Enterectomy
Pneumatosis intestinalis
Carcinoid
Enterochromaffin cells
Jejunum
Small intestine
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Summary:Neuroendocrine tumors represent a heterogeneous group of neoplasms that arise from neuroendocrine cells and secrete various peptides and bioamines. While gastrointestinal neuroendocrine tumors,commonly called carcinoids,account for about 2/3 of all neuroendocrine tumors,they are relatively rare. Small intestine neuroendocrine tumors originate from intestinal enterochromaffin cells and represent about 1/4 of small intestine neoplasms. They can be asymptomatic or cause nonspecific symptoms,which usually leads to a delayed diagnosis. Imaging modalities can aid diagnosis and surgery remains the mainstay of treatment. We present a case of a jejunal neuroendocrine tumor that caused nonspecific symptoms for about 1 year before manifesting with acute mesenteric ischemia. Abdominal X-rays revealed pneumatosis intestinalis and an abdominal ultrasound and computed tomography confirmed the diagnosis. The patient was submitted to segmental enterectomy. Histopathological study demonstrated a neuroendocrine tumor with perineural and arterial infiltration and lymph node metastasis. The postoperative course was uneventful and the patient denied any adjuvant treatment.
Bibliography:Ioannis Mantzoros;Natalia Antigoni Savvala;Orestis Ioannidis;Styliani Parpoudi;Lydia Loutzidou;Despoina Kyriakidou;Angeliki Cheva;Vasileios Intzos;Konstantinos Tsalis;Fourth Surgical Department,Faculty of Health Science,School of Medicine,Aristotle Uni-versity of Thessaloniki,'G. Papanikolaou' General Hospital;Department of Pathology,General Hospital 'G. Papanikolaou';Department of Radiology,General Hospital 'G. Papanikolaou'
ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
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Telephone: +30-231-0814161 Fax: +30-231-0551301
Author contributions: Mantzoros I, Savvala NA, Ioannidis O and Tsalis K designed the report; Mantzoros I, Savvala NA, Ioannidis O, Parpoudi S, Loutzidou L and Tsalis K contributed to the clinical diagnosis, evaluation and management of the patient; Parpoudi S, Loutzidou L and Kyriakidou D collected the patient’s clinical data; Cheva A performed the histopathologic analysis; Intzos V performed the radiological studies; Mantzoros I, Savvala NA, Ioannidis O and Tsalis K analyzed the data and drafted the paper; all authors discussed the results and commented and contributed to this manuscript.
Correspondence to: Dr. Orestis Ioannidis, MD, MSC, PhD, Surgeon, Scientific Fellow, Fourth Surgical Department, Medical School, Aristotle University of Thessaloniki, Alexandrou Mihailidi 13, Thessaloniki 54640, Greece. iorestis@auth.gr
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v23.i45.8090