Antifertility effect in male rats of oleanolic acid, a triterpene from Eugenia jambolana flowers

The antifertility activity of oleanolic acid (C30H48O3), isolated from the flowers of Eugenia jambolana, was evaluated in male albino rats. The administration of the compound for 60 days decreased the fertilizing capacity of the animals without any significant changes in body weight or reproductive...

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Bibliographic Details
Published in:	Journal of ethnopharmacology Vol. 24; no. 1; p. 115
Main Authors:	Rajasekaran, M, Bapna, J S, Lakshmanan, S, Ramachandran Nair, A G, Veliath, A J, Panchanadam, M
Format:	Journal Article
Language:	English
Published:	Ireland 01-09-1988
Subjects:	Animals Contraceptive Agents, Male Male Oleanolic Acid - isolation & purification Oleanolic Acid - pharmacology Plants, Medicinal Rats Rats, Inbred Strains Sapogenins - pharmacology Spermatogenesis - drug effects Testis - anatomy & histology Testis - drug effects
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Summary:	The antifertility activity of oleanolic acid (C30H48O3), isolated from the flowers of Eugenia jambolana, was evaluated in male albino rats. The administration of the compound for 60 days decreased the fertilizing capacity of the animals without any significant changes in body weight or reproductive organ weights. The compound produced arrest of spermatogenesis but did not cause any abnormality to spermatogenic cells, Leydig interstitial cells and Sertoli cells. Oleanolic acid may prove to be a promising antifertility agent devoid of undesirable side effects.
ISSN:	0378-8741
DOI:	10.1016/0378-8741(88)90142-0