Design, preparation and in vitro characterizations of fluconazole loaded nanostructured lipid carriers

• Published in: Brazilian Journal of Pharmaceutical Sciences Vol. 56
• Main Authors: Fernandes, Amanda Velinna, Pydi, Chinna Raja, Verma, Ruchi, Jose, Jobin, Kumar, Lalit
• Format: Journal Article
• Language: English
• Published: Sao Paulo Universidade de Sao Paulo Faculdade de Ciencias 01-01-2020; Universidade de São Paulo, Faculdade de Ciências Farmacêuticas; Universidade de São Paulo
• Subjects: Acids; Antifungal agents; Design of experiment; Drug delivery systems; Drugs; Fluconazole; Full factorial design; Fungal infections; Laboratories; Lipids; Microemulsions; Nanoparticles; Nanostructured lipid carriers; NLCs; Particle size; Patient compliance; PHARMACOLOGY & PHARMACY; Skin; Spectrum analysis; Surfactants; Mumbai India; India; Nanostructured lipid carriers; Full factorial design; NLCs; Fungal infections; Fluconazole; Design of experiment
• ISSN: 2175-9790; 1984-8250; 2175-9790
• DOI: 10.1590/s2175-97902019000318069

Present study was aimed to prepare and characterize fluconazole loaded nanostructured lipid carriers (FLZ-NLCs) for the treatment of fungal infections. Fungal infections are tremendously widespread and are the often faced dermatological condition worldwide. FLZ-NLCs was prepared by ultrasonication emulsion technique using stearic acid (SA) as solid lipid, castor oil as liquid lipid and tween 20 as a surfactant. The mean diameter of optimized FLZ-NLCs were found to be 359.15 ± 9.83 nm. The drug content and entrapment efficiency of NLCs was found to be 102.97 ± 7.45% and 87 ± 0.59%, respectively. In vitro drug release studies of FLZ-NLCs showed 37.34 ± 2.08% drug release over a period of 72 h. The above studies confirmed the prepared FLZ-NLCs may be useful for the treatment of fungal infections.