Diffuse large cell non-Hodgkin lymphoma with pituitary and bilateral adrenal involvement

• Published in: Internal medicine journal Vol. 42; no. 3; pp. 329 - 332
• Main Authors: Wang, X.-L., Lü, Z.-H., Mu, Y.-M., Dou, J.-T., Lu, J.-M., Zhong, W.-W., Pan, C.-Y.
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Publishing Asia 01-03-2012
• Subjects: adrenal; Adrenal Glands - diagnostic imaging; Adrenal Glands - pathology; Aged; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Cyclophosphamide - administration & dosage; Cyclophosphamide - adverse effects; Dexamethasone - administration & dosage; Dexamethasone - adverse effects; Doxorubicin - administration & dosage; Doxorubicin - adverse effects; Fatal Outcome; fever of unknown origin; Fever of Unknown Origin - etiology; Humans; hyponatraemia; Hyponatremia - etiology; Hyponatremia - physiopathology; Lymphoma, Large B-Cell, Diffuse - complications; Lymphoma, Large B-Cell, Diffuse - diagnostic imaging; Lymphoma, Large B-Cell, Diffuse - drug therapy; Lymphoma, Large B-Cell, Diffuse - pathology; Male; Methotrexate - administration & dosage; Methotrexate - adverse effects; Multimodal Imaging; non-Hodgkin lymphoma; pituitary; Pituitary Gland - diagnostic imaging; Pituitary Gland - pathology; Pituitary-Adrenal System - physiopathology; Positron-Emission Tomography; Prednisone - administration & dosage; Prednisone - adverse effects; Tomography, X-Ray Computed; Ultrasonography; Vincristine - administration & dosage; Vincristine - adverse effects
• ISSN: 1444-0903; 1445-5994
• DOI: 10.1111/j.1445-5994.2011.02691.x

We describe an elderly male patient who presented with fever of unknown origin and refractory hyponatraemia. Following 18fluorine‐fluorodeoxyglucose positron emission tomography/computed tomography scan and core adrenal biopsy, the diagnosis of diffuse large B‐cell non‐Hodgkin lymphoma with pituitary and bilateral adrenal involvement was confirmed. After chemotherapy, his symptoms resolved, and all the lesions shrank significantly.