HLA-B0811: another example of a single point substitution of the HLA-B0801 allele

• Published in: Tissue antigens Vol. 56; no. 5; pp. 457 - 459
• Main Authors: Magira, E., Beznik-Cizman, B., Monos, D.
• Format: Journal Article
• Language: English
• Published: Copenhagen Munksgaard International Publishers 01-11-2000
• Subjects: alanine; Alleles; Amino Acid Substitution; Base Sequence; DNA sequencing; DNA, Complementary; histocompatibility locus HLA; HLA-B Antigens - genetics; HLA-B0801; HLA-B0811; Humans; Molecular Sequence Data; point mutations; threonine
• ISSN: 0001-2815; 1399-0039
• DOI: 10.1034/j.1399-0039.2000.560511.x

Acknowledgments:
This work was supported in part by office of Naval Research cooperative agreement # N‐00014‐96‐2‐0016 to the National Marrow Donor Program and by funding from the E.B. Foerderer Fund of the Children’s Hospital of Philadelphia to D.M.
:
The described alle HLA‐B*0811 is of Caucasoid origin. Most likely it derived from a point mutation of the B*0801 allele at position 559, where an adenine was converted to guanine. This position corresponds to codon 163 and resulted in an amino acid change from threonine to alanine. This substitution may influence both, T‐cell interactions and/or peptide binding ( Note).