Site α Is Crucial for Two Routes of IFNγ-Induced MHC Class I Transactivation: The ISRE-Mediated Route and a Novel Pathway Involving CIITA

The constitutive and cytokine-induced levels of major histocompatibility (MHC) class I expression are tightly controlled at the transcriptional level. In this study, it is shown that the cis-acting regulatory element site α of the MHC class I promoter is essential for the IFNγ-induced transactivatio...

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Vol. 6; no. 5; pp. 601 - 611
Main Authors: Gobin, Sam J.P, Peijnenburg, Ad, Keijsers, Vivian, van den Elsen, Peter J
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-05-1997
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Summary:The constitutive and cytokine-induced levels of major histocompatibility (MHC) class I expression are tightly controlled at the transcriptional level. In this study, it is shown that the cis-acting regulatory element site α of the MHC class I promoter is essential for the IFNγ-induced transactivation of MHC class I gene expression through the ISRE. Moreover, it was discovered that the class II transactivator (CIITA), which is itself under the control of the IFNγ induction pathway, strongly transactivates MHC class I gene expression and exerts its activity through site α. Therefore, site α is a crucial regulatory element, mediating the classic route of IFNγ induction via the ISRE as well as a novel route of MHC class I transactivation involving CIITA.
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ISSN:1074-7613
1097-4180
DOI:10.1016/S1074-7613(00)80348-9