Waterborne aripiprazole blunts the stress response in zebrafish

• Published in: Scientific reports Vol. 6; no. 1; p. 37612
• Main Authors: Barcellos, Heloísa Helena de Alcantara, Kalichak, Fabiana, da Rosa, João Gabriel Santos, Oliveira, Thiago Acosta, Koakoski, Gessi, Idalencio, Renan, de Abreu, Murilo Sander, Giacomini, Ana Cristina Varrone, Fagundes, Michele, Variani, Cristiane, Rossini, Mainara, Piato, Angelo L, Barcellos, Leonardo José Gil
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22-11-2016; Nature Publishing Group
• Subjects: 631/378/1831; 64; 64/116; 704/172/4081; Animals; Aripiprazole; Aripiprazole - toxicity; Female; Fish; Homeostasis; Humanities and Social Sciences; Hydrocortisone - metabolism; Male; multidisciplinary; Science; Stress response; Stress, Physiological - drug effects; Water Pollutants, Chemical - toxicity; Zebrafish; Zebrafish - physiology
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/srep37612

Here we provide, at least to our knowledge, the first evidence that aripiprazole (APPZ) in the water blunts the stress response of exposed fish in a concentration ten times lower than the concentration detected in the environment. Although the mechanism of APPZ in the neuroendocrine axis is not yet determined, our results highlight that the presence of APPZ residues in the environment may interfere with the stress responses in fish. Since an adequate stress response is crucial to restore fish homeostasis after stressors, fish with impaired stress response may have trouble to cope with natural and/or imposed stressors with consequences to their welfare and survival.