Development and homeostasis of the skin epidermis

The skin epidermis is a stratified epithelium that forms a barrier that protects animals from dehydration, mechanical stress, and infections. The epidermis encompasses different appendages, such as the hair follicle (HF), the sebaceous gland (SG), the sweat gland, and the touch dome, that are essent...

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Bibliographic Details
Published in:	Cold Spring Harbor perspectives in biology Vol. 4; no. 7; p. a008383
Main Authors:	Sotiropoulou, Panagiota A, Blanpain, Cedric
Format:	Journal Article
Language:	English
Published:	United States Cold Spring Harbor Laboratory Press 01-07-2012
Subjects:	Animals Cell Proliferation Concepts Epidermis - cytology Epidermis - growth & development Epidermis - physiology Genomics Homeostasis Humans Signal Transduction Stem Cells - cytology
Online Access:	Get full text
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Summary:	The skin epidermis is a stratified epithelium that forms a barrier that protects animals from dehydration, mechanical stress, and infections. The epidermis encompasses different appendages, such as the hair follicle (HF), the sebaceous gland (SG), the sweat gland, and the touch dome, that are essential for thermoregulation, sensing the environment, and influencing social behavior. The epidermis undergoes a constant turnover and distinct stem cells (SCs) are responsible for the homeostasis of the different epidermal compartments. Deregulation of the signaling pathways controlling the balance between renewal and differentiation often leads to cancer formation.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1943-0264 1943-0264
DOI:	10.1101/cshperspect.a008383