Biocompatible bacterial cellulose membrane in dural defect repair of rat

• Published in: Journal of materials science. Materials in medicine Vol. 28; no. 3; pp. 37 - 7
• Main Authors: Lima, Frederico de Melo Tavares de, Pinto, Flávia Cristina Morone, Andrade-da-Costa, Belmira Lara da Silveira, Silva, Jaiurte Gomes Martins da, Campos Júnior, Olávio, Aguiar, José Lamartine de Andrade
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-03-2017; Springer Nature B.V
• Subjects: Animals; Bacteria; Bacteria - chemistry; Biocompatibility; Biocompatibility Studies; Biocompatible Materials - chemistry; Biomaterials; Biomedical Engineering and Bioengineering; Biomedical materials; Cellulose; Cellulose - chemistry; Ceramics; Chemistry and Materials Science; Composites; Defects; Dura Mater - drug effects; Dura Mater - injuries; Glass; Immune System; Inflammation; Male; Materials Science; Membranes; Molasses; Natural Materials; Polymer Sciences; Rats; Rats, Wistar; Regenerative Medicine/Tissue Engineering; Repair; Saccharum; Surfaces and Interfaces; Thin Films; Wound Healing; Sugarcane Molas; Bacterial Cellulose Membrane; Dural Substitute; Bacterial Cellulose; Bacterial Cellulose Film
• ISSN: 0957-4530; 1573-4838
• DOI: 10.1007/s10856-016-5828-9

Duraplasty is necessary in nearly 30% of all neurological surgeries. Different tissues and materials have been evaluated in dura mater repair or as dural substitutes in neurosurgery. The aim was to evaluate the biocompatibility of the bacterial cellulose (BC) membranes, produced from sugarcane molasses, for dural defect repair in rats. Forty adults males Wistar rats divided into two groups: a control (ePTFE) and an experimental (BC). Bilateral frontoparietal craniectomy was performed, and a dural defect was created. The arachnoid underlying defect was disrupted with a narrow hook. The animals were observed for 120 days. There were no cases of infection, cerebrospinal fluid fistulae, delayed hemorrhages, behavior disturbances, seizures and palsies. The BC membrane showed to have suitable biocompatibility properties, was not induced immune reaction, nor chronic inflammatory response and absence of neurotoxicity signals.
Graphical Abstract