Stereotactic Body Radiotherapy for Pulmonary Oligometastases from Esophageal Cancer: Results and Prognostic Factors

• Published in: Anticancer research Vol. 40; no. 4; pp. 2065 - 2072
• Main Authors: Yamamoto, Takaya, Niibe, Yuzuru, Matsumoto, Yasuo, Dekura, Yasuhiro, Oh, Ryoong-Jin, Yamashita, Hideomi, Kakuhara, Hisao, Aoki, Masahiko, Jingu, Keiichi
• Format: Journal Article
• Language: English
• Published: Greece International Institute of Anticancer Research 01-04-2020
• Subjects: Adult; Aged; Aged, 80 and over; Cancer; Disease-Free Survival; Esophageal cancer; Esophageal Neoplasms - epidemiology; Esophageal Neoplasms - pathology; Esophageal Neoplasms - radiotherapy; Esophagus; Female; Humans; Identification methods; Kaplan-Meier Estimate; Lung cancer; Lung Neoplasms - epidemiology; Lung Neoplasms - pathology; Lung Neoplasms - radiotherapy; Lung Neoplasms - secondary; Male; Medical prognosis; Metastases; Metastasis; Middle Aged; Neoplasm Metastasis; Proportional Hazards Models; Radiation therapy; Radiosurgery; Regression analysis; Survival; Stereotactic body radiotherapy (SBRT); oligo-recurrence; esophageal cancer; prognostic factor; oligometastases
• ISSN: 0250-7005; 1791-7530
• DOI: 10.21873/anticanres.14164

The aim of this multi-center retrospective study was to investigate the results of stereotactic body radiotherapy (SBRT) for pulmonary oligometastases from esophageal cancer.
Oligometastases from the esophagus were identified from a dataset of a Japanese survey. The Kaplan-Meier method and Cox regression were applied to perform analyses.
A total of 114 patients with 132 pulmonary oligometastases were collected. The 3-year local control rate, freedom from further metastasis (FFFM) rate and overall survival (OS) rate were 70.2%, 25.3% and 37.5%, respectively. Performance status (PS) (PS 1 vs. PS 0, p<0.01), disease-free interval (p=0.03) and history of local therapy for metastasis (p=0.01) had significant relationships with FFFM and only PS was an independent prognostic factor for OS (PS 1 vs. PS 0, p=0.02; PS 2-3 vs. PS 0, p=0.04).
SBRT for pulmonary oligometastases from esophageal cancer provided good local control and survival.