So-called carcinosarcoma of the duodenum with a chondrosarcomatous component

• Published in: Clinical journal of gastroenterology Vol. 8; no. 5; pp. 268 - 274
• Main Authors: Tanaka, Hiroki, Baba, Youichirou, Matsusaki, Shimpei, Isono, Yoshiaki, Kumazawa, Hiroaki, Sase, Tomohiro, Okano, Hiroshi, Saito, Tomonori, Mukai, Katsumi, Taoka, Hiroki
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01-10-2015
• Subjects: Abdominal Surgery; Aged; Carcinosarcoma - metabolism; Carcinosarcoma - pathology; Carcinosarcoma - surgery; Case Report; Colorectal Surgery; Duodenal Neoplasms - metabolism; Duodenal Neoplasms - pathology; Duodenal Neoplasms - surgery; Gastroenterology; Hepatology; Humans; Immunohistochemistry; Keratins - metabolism; Male; Medicine; Medicine & Public Health; Pancreaticoduodenectomy; Surgical Oncology; Vimentin - metabolism; So-called carcinosarcoma; Duodenum; Sarcomatoid carcinoma; Chondrosarcoma component
• ISSN: 1865-7257; 1865-7265
• DOI: 10.1007/s12328-015-0595-6

Carcinosarcoma is a biphasic malignant tumor consisting of both carcinomatous and sarcomatous components, and its occurrence in the duodenum is very rare. In the present report, we describe a case of so-called carcinosarcoma of the duodenum with a chondrosarcomatous component. A 79-year-old man was referred to our hospital because of anorexia, weight loss, and jaundice. A preoperative imaging examination showed a hypovascular mass located in the pancreatic head. Histological examination of specimens obtained through a forceps biopsy revealed anaplastic carcinoma (spindle cell type), and a pancreatoduodenectomy was performed. Histologically, the tumor showed an elevated lesion with a wide base in proximity to duodenal mucosal carcinoma. The tumor was found to be predominantly composed of sarcoma with carcinomatous and chondrosarcomatous components. There was a transitional zone between the carcinomatous and sarcomatous components, and a portion of the sarcomatous component was positive for cytokeratin, and negative for vimentin. As mentioned above, we diagnosed the lesion as so-called carcinosarcoma with a chondrosarcomatous component.