Modulation by casein and soybean protein amino acid mixtures of insulin- and glucagon-dependent linoleic acid desaturation in primary-cultured rat hepatocytes

• Published in: Bioscience, biotechnology, and biochemistry Vol. 58; no. 6; pp. 1073 - 1076
• Main Authors: Koba, K. (Kyushu Univ., Fukuoka (Japan). Faculty of Agriculture), Imaizumi, K, Obata, K, Hirata, K, Sugano, M
• Format: Journal Article
• Language: English
• Published: Tokyo Taylor & Francis 1994; Japan Society for Bioscience Biotechnology and Agrochemistry; Oxford University Press
• Subjects: ACIDE AMINE; ACIDE LINOLEIQUE; ACIDO LINOLEICO; AMINOACIDOS; Biological and medical sciences; CASEINA; CASEINE; FISIOLOGIA DE LA NUTRICION; FOIE; Fundamental and applied biological sciences. Psychology; GLUCAGON; HIGADO; INSULINA; INSULINE; Lipids. Glycolipids; Metabolisms and neurohumoral controls; PHYSIOLOGIE DE LA NUTRITION; POLIMORFISMO BIOQUIMICO; POLYMORPHISME BIOCHIMIQUE; RAT; RATA; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Culture medium; Pancreatic hormone; Nutrition; Glucagon; Rat; Liver; Rodentia; Polyunsaturated fatty acid; Lipids; Metabolism; In vitro; Insulin; Linoleic acid; Vertebrata; Mammalia; Hepatocyte; Aminoacid; Modulation; Hormonal regulation; Primary culture; Nutrient; Desaturation
• ISSN: 0916-8451; 1347-6947
• DOI: 10.1271/bbb.58.1073

The effects of amino acid mixtures simulating to casein and soybean protein on insulin- and glucagon-dependent linoleic acid desaturation were studied in rat hepatocytes of up to 72h of culture. The desaturation increased with the insulin molarity in the medium, but decreased with the glucagon molarity. The soybean protein type of amino acid mixture, compared to the casein type of amino acid mixture, potentiated the insulin-dependent desaturation. Thus, dietary proteins could modify in vivo insulin-dependent intracellular metabolism through postprandial amino acids in blood plasma