Isolation, characterization and geographic distribution of Caño Delgadito virus, a newly discovered South American hantavirus (family Bunyaviridae)

Rodents collected from the Venezuelan llanos (plains) during field studies of viral hemorrhagic fever were tested for evidence of hantavirus infection. Hantavirus antibody was found in one (7.7%) of 13 Oryzomys bicolor, one (3.4%) of 29 Rattus rattus, 10 (6.0%) of 166 Sigmodon alstoni and one (2.2%)...

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Bibliographic Details
Published in:	Virus research Vol. 51; no. 2; pp. 159 - 171
Main Authors:	Fulhorst, Charles F, Monroe, Martha C, Salas, Rosa Alba, Duno, Gloria, Utrera, Antonio, Ksiazek, Thomas G, Nichol, Stuart T, de Manzione, Nuris M.C, Tovar, Duilia, Tesh, Robert B
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-10-1997
Subjects:	Animals Caño Delgadito virus Hantavirus - classification Hantavirus - genetics Hantavirus - immunology Hantavirus - isolation & purification Lung - virology Muridae - virology Phylogeny Polymerase Chain Reaction - methods Rats RNA, Viral - analysis Rodentia - virology Rodents Sigmodontinae - virology South America South American hantavirus Venezuela South America Venezuela Caño Delgadito virus South American hantavirus Rodents
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Summary:	Rodents collected from the Venezuelan llanos (plains) during field studies of viral hemorrhagic fever were tested for evidence of hantavirus infection. Hantavirus antibody was found in one (7.7%) of 13 Oryzomys bicolor, one (3.4%) of 29 Rattus rattus, 10 (6.0%) of 166 Sigmodon alstoni and one (2.2%) of 45 Zygodontomys brevicauda. Hantavirus-specific RNA was detected in lung tissues from four antibody-positive rodents: two S. alstoni from Portuguesa State and one S. alstoni each from Cojedes and Barinas States. A hantavirus isolate (herein identified as VHV-574) was recovered from lung tissue from a hantavirus RNA-positive S. Alstoni collected from Portuguesa State. The results of serological tests and analyses of small and medium RNA segment nucleotide sequence data indicated that VHV-574 represents a novel hantavirus (proposed name ‘Caño Delgadito’) that is distinct from all previously characterized hantaviruses. The results of analyses of nucleotide sequence data from the four hantavirus RNA-positive S. alstoni suggested that Caño Delgadito virus is widely distributed in the Venezuelan llanos.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0168-1702 1872-7492
DOI:	10.1016/S0168-1702(97)00091-9