Serum lipids and lipoproteins in type 2 diabetic patients with persistent microalbuminuria

• Published in: Diabetic medicine Vol. 7; no. 9; p. 810
• Main Authors: Seghieri, G, Alviggi, L, Caselli, P, De Giorgio, L A, Breschi, C, Gironi, A, Niccolai, M, Bartolomei, G C
• Format: Journal Article
• Language: English
• Published: England 01-11-1990
• Subjects: Albuminuria; Apolipoprotein A-I; Apolipoproteins A - blood; Apolipoproteins B - blood; Blood Pressure; Cholesterol - blood; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - physiopathology; Diabetes Mellitus, Type 2 - urine; Female; Humans; Lipoproteins - blood; Lipoproteins, HDL - blood; Male; Middle Aged; Triglycerides - blood
• ISSN: 0742-3071
• DOI: 10.1111/j.1464-5491.1990.tb01497.x

To investigate whether persistent microalbuminuria is related to altered levels of both lipids and apolipoproteins in Type 2 diabetes mellitus serum total-cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, apolipoprotein A-I, and apolipoprotein B were measured by standard methods in a group of Type 2 diabetic patients affected by persistent microalbuminuria (albumin excretion rate (AER) 20-200 micrograms min-1) as compared with a group of sex- and age-matched non-microalbuminuric patients (AER less than 20 micrograms min-1). The groups were stratified according to a short (less than or equal to 5 years) or a longer (greater than 5 years) duration of diagnosed diabetes. Microalbuminuria was not associated with significant changes of serum total-cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, and apolipoproteins in the group of patients with a duration of disease greater than 5 years, while microalbuminuric patients less than or equal to 5 years from diagnosis (n = 11) had serum total-cholesterol, triglycerides, LDL-cholesterol, and apoprotein B higher than non-microalbuminuric control patients (n = 26) (cholesterol 6.2 +/- 0.9 vs 5.1 +/- 1.0 mmol l-1 (p = 0.003); triglycerides 2.1 +/- 0.7 vs 1.7 +/- 1.3 mmol l-1 (p = 0.03); LDL-cholesterol 4.1 +/- 0.8 vs 3.0 +/- 0.7 mmol l-1 (p less than 0.001); apo-B 1.3 +/- 0.3 vs 1.1 +/- 0.3 g l-1 (p = 0.02). In these patients with shorter duration of diabetes many of the serum lipid measures correlated positively with AER.