Effects of lactoferrin, soya germ and polyamine on 2-amino-1-methyl-6- phenylimidazo[4,5-b]-pyridine(PhIP)- induced breast carcinogenesis in rats

• Published in: BioFactors (Oxford) Vol. 22; no. 1-4; pp. 127 - 131
• Main Authors: Haba, Ryota, Watanabe, Shaw, Wada, Masahiro, Udaka, Shigezo
• Format: Journal Article
• Language: English
• Published: Amsterdam IOS Press 2004
• Subjects: Animals; cancer prevention; Carcinogens - toxicity; Cell Division - drug effects; Disease Models, Animal; Female; Glycine max; Imidazoles - toxicity; isoflavone; lactoferrin; Lactoferrin - pharmacology; mammary carcinogenesis; Mammary Neoplasms, Experimental - chemically induced; Mammary Neoplasms, Experimental - pathology; Mammary Neoplasms, Experimental - prevention & control; Phytotherapy; Plant Extracts - pharmacology; polyamine; Rats; Rats, Sprague-Dawley; Seeds
• ISSN: 0951-6433; 1872-8081
• DOI: 10.1002/biof.5520220125

The cancer‐preventive effects of food‐derived bovine lactoferrin(bLF), isoflavone‐rich soya germ(SG), and spermidine(SPD) on mammary gland carcinogenesis induced by 2‐amino‐1‐ methyl‐6‐phenylimidazo[4,5‐b]‐pyridine (PhIP), were investigated in female Sprague‐Dawley(SD) rats. Two hundred and six female SD rats were divided into 8 groups. Cumulative breast cancer incidence at 43 weeks was 65.4% in the PhIP group; 80.0% and 76.0% in the 0.2% and 2.0% bLF groups, respectively; 58.3% and 20.0% in the 2% and 10% SG groups, respectively; and 80.0% and 76.9% in the 0.035% and 0.175% SPD groups, respectively. Isoflavone‐rich SG significantly suppressed breast cancer, and the tumors showed fibrous or less malignant features upon histological examination.