Efficacy and tolerability of methotrexate in severe childhood alopecia areata

• Published in: British journal of dermatology (1951) Vol. 165; no. 2; pp. 407 - 410
• Main Authors: Royer, M., Bodemer, C., Vabres, P., Pajot, C., Barbarot, S., Paul, C., Mazereeuw, J.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01-08-2011; Wiley-Blackwell
• Subjects: Adolescent; Alopecia Areata - drug therapy; Biological and medical sciences; Child; Dermatologic Agents - administration & dosage; Dermatologic Agents - adverse effects; Dermatology; Drug Administration Schedule; Drug Resistance; Female; General aspects; Hair and nails disorders; Humans; Male; Medical sciences; Methotrexate - administration & dosage; Methotrexate - adverse effects; Retrospective Studies; Treatment Outcome; Human; Antineoplastic agent; Hair (head); Hair; Skin disease; Dermatology; Antirheumatic agent; Methotrexate; Child; Alopecia areata
• ISSN: 0007-0963; 1365-2133
• DOI: 10.1111/j.1365-2133.2011.10383.x

Summary
Background  Alopecia areata (AA) occurring in childhood is associated with a poorer prognosis than adult AA and may severely affect quality of life. The efficacy of methotrexate (MTX) was reported in adults with AA but there is little information about its use in children.
Objectives  We aimed to assess the efficacy and safety of MTX in severe childhood AA.
Methods  We conducted a retrospective study including children with severe AA treated with MTX in the Departments of Paediatric Dermatology in France between November 2005 and December 2009.
Results  Fourteen children (eight girls and six boys) aged between 8 and 18 years (mean 14·7) were included. AA was present for a mean duration of 5·7 years (range 2 months–11 years 8 months). The treatment was administered once weekly, the mean maximal dose was 18·9 mg weekly (range 15–25) and the mean duration of treatment was 14·2 months (range 1–31). Thirteen children were assessable. Of these 13 children, MTX was considered as successful (regrowth > 50% of hair) for five of them. The remaining eight children were considered treatment failures. No serious side‐effects were reported.
Conclusions  The efficacy of MTX in children with severe AA is variable. MTX may be considered for severe childhood AA in the absence of alternative effective treatments.