AS1411 aptamer-targeted gold nanoclusters effect on the enhancement of radiation therapy efficacy in breast tumor-bearing mice

Herein, the AS1411 aptamer-targeted ultrasmall gold nanoclusters (GNCs) were assessed at different aspects as a radiosensitizer. AS1411 aptamer-conjugated gold nanoclusters (Apt-GNCs) efficacy was evaluated at cancer cells targeting, radiosensitizing effect, tumor targeting, and biocompatibility in...

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Bibliographic Details
Published in:	Nanomedicine (London, England) Vol. 13; no. 20; pp. 2563 - 2578
Main Authors:	Ghahremani, Fatemeh, Kefayat, Amirhosein, Shahbazi-Gahrouei, Daryoush, Motaghi, Hasan, Mehrgardi, Masoud A, Haghjooy-Javanmard, Shaghayegh
Format:	Journal Article
Language:	English
Published:	England Future Medicine Ltd 01-10-2018
Subjects:	4T1 Animals Aptamers, Nucleotide - administration & dosage Aptamers, Nucleotide - chemistry AS1411 aptamer biocompatibility Brain cancer Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - pathology Breast Neoplasms - radiotherapy breast tumors cancer Cancer therapies Cell Line, Tumor Drug Delivery Systems Drug dosages Female Flow Cytometry Fourier transforms gold nanoclusters Hemodialysis Humans Medical research Metal Nanoparticles - administration & dosage Metal Nanoparticles - chemistry Mice Nanoparticles nucleolin Oligodeoxyribonucleotides - administration & dosage Oligodeoxyribonucleotides - chemistry Radiation therapy Radiation-Sensitizing Agents - administration & dosage Radiation-Sensitizing Agents - chemistry radiosensitizer tumor targeting Tumors United States > US Japan 4T1 breast tumors tumor targeting biocompatibility gold nanoclusters radiation therapy AS1411 aptamer cancer radiosensitizer nucleolin
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