Factor V Deficiency Associated with Congenital Cardiac Disorder and Intracranial Hemorrage

• Published in: Indian journal of hematology & blood transfusion Vol. 29; no. 2; pp. 99 - 101
• Main Authors: Özkaya, Halit, Akcan, A. Barıs, Aydemir, Gökhan, Akcan, Mediha, Kul, Mustafa
• Format: Journal Article
• Language: English
• Published: India Springer-Verlag 01-06-2013; Springer Nature B.V
• Subjects: Blood Transfusion Medicine; Case Report; Coagulation; Congenital diseases; Hematology; Hemorrhage; Human Genetics; Medicine; Medicine & Public Health; Oncology; İntracranial hemorrage; Factor V deficiency; Bleeding disorder
• ISSN: 0971-4502; 0974-0449; 0974-0449; 0971-4502
• DOI: 10.1007/s12288-012-0149-8

Factor V deficiency is an inherited disorder, in which the clotting factor V is low. The disorder is very rare, occurring in only one in one million people. It is inherited as an autosomal recessive disorder. The results of coagulation studies include a prolonged prothrombin time and partial thromboplastin time associated with reduced plasma factor V content. Patients with factor V deficiency have a hemophiliac like hemorrhagic disorder. Epistaxis, bruising, and menorrhagia are some of the common features. If treatment is needed, fresh frozen plasma is typically given. In this report we present a 12 year old girl who was admitted to our clinic with recurrent nosebleeds and intracranial hemorrage after head trauma. After examination, factor V deficiency was diagnosed. She also had congenital cardiac disorder (VSD), probably a co-incidental finding.