Epidermal innervation as a tool to study human axonal regeneration and disease progression

Epidermal innervation as a tool to study human axonal regeneration and disease progression

•Animal models of axonal regeneration have not translated well to human studies.•Epidermal nerve is attractive to directly study axonal regeneration in human subjects.•Regenerative and collateral sprouting can be efficiently measured in human skin.

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Bibliographic Details
Published in:Experimental neurology Vol. 287; no. Pt 3; pp. 358 - 364
Main Authors: Khoshnoodi, Mohammad A., Ebenezer, Gigi J., Polydefkis, Michael
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-01-2017
Subjects:
Animals
Axons - physiology
Axotomy - methods
Disease Progression
Epidermis - innervation
Epidermis - pathology
Epidermis - physiology
Humans
Nerve Regeneration - physiology
Neuralgia - pathology
Neuralgia - physiopathology
Online Access:Get full text
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Description
Summary:•Animal models of axonal regeneration have not translated well to human studies.•Epidermal nerve is attractive to directly study axonal regeneration in human subjects.•Regenerative and collateral sprouting can be efficiently measured in human skin.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0014-4886
1090-2430
DOI:10.1016/j.expneurol.2016.06.016