Preparation of molecularly imprinted polymers in supercritical carbon dioxide

• Published in: Journal of applied polymer science Vol. 102; no. 3; pp. 2863 - 2867
• Main Authors: Ye, Lei, Yoshimatsu, Keiichi, Kolodziej, Dorota, Da Cruz Francisco, José, Dey, Estera S.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 05-11-2006; Wiley
• Subjects: Applied sciences; Biochemistry and Molecular Biology; Biokemi och molekylärbiologi; Biologi; Biological Sciences; Exact sciences and technology; molecular imprinting; Natural Sciences; Naturvetenskap; Organic polymers; Physicochemistry of polymers; Polymers with particular properties; Preparation, kinetics, thermodynamics, mechanism and catalysts; propranolol; supercritical carbon dioxide; Methacrylic acid polymer; Enantioselectivity; Nanoparticle; Carbon dioxide; Experimental study; Heterogeneous polymerization; Polyelectrolyte; Free radical polymerization; supercritical carbon dioxide; Binding capacity; Template polymerization; Preparation; Crosslinked polymer; Supercritical solvent; Propranolol; Molecular imprinting
• ISSN: 0021-8995; 1097-4628; 1097-4628
• DOI: 10.1002/app.24648

Molecularly imprinted polymer nanoparticles were prepared in supercritical carbon dioxide using a noncovalent imprinting approach. In the present work, propranolol was used as a model template, methacrylic acid as a functional monomer, and divinylbenzene as a crosslinker. Under a high dilution condition, the heterogeneous polymerization resulted in discrete crosslinked polymer nanoparticles. Compared with the nonimprinted polymers, the imprinted nanoparticles displayed much higher propranolol uptake in a low polarity organic solvent. The use of a single enantiomer (S)‐propranolol as the template clearly demonstrated that the imprinted binding sites are chiral‐selective, with a cross‐reactivity towards (R)‐propranolol of less than 5%. The overall binding performance of the imprinted nanoparticles was comparable to imprinted polymers prepared in conventional organic solvents. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 2863–2867, 2006