Do mitochondrial DNA haplogroups play a role in susceptibility to tuberculosis?

• Published in: Respirology (Carlton, Vic.) Vol. 12; no. 6; pp. 823 - 827
• Main Authors: HOUSHMAND, Massoud, BANOEI, Mohammad Mehdi, TABARSI, Payam, PANAHI, Mehdi Shafa Shariat, KASHANI, Baharak Hooshiar, EBRAHIMI, Golnaz, ZARGAR, Laleh, FARNIA, Parissa, MORRIS, Matthew W., MANSOURI, Davood, VELAYATI, Ali Akbar, MIRSAEIDI, Mehdi S.
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Publishing Asia 01-11-2007
• Subjects: Adult; DNA, Mitochondrial - genetics; Female; Genetic Predisposition to Disease - genetics; haplogroups; Haplotypes; Humans; Male; Middle Aged; mitochondria; Mycobacterium tuberculosis; Polymorphism, Single Nucleotide; susceptibility; tuberculosis; Tuberculosis, Pulmonary - genetics
• ISSN: 1323-7799; 1440-1843
• DOI: 10.1111/j.1440-1843.2007.01163.x

Background and objectives:  Mitochondrial DNA has a unique role in ATP production and subsequent mitochondrial reactive oxygen species (ROS) production in eukaryotic cells and there is a potential role for ROS and oxygen burst against Mycobacterium tuberculosis, an intracellular pathogen. This study aimed to determine whether the frequency of different mitochondrial haplogroups was significantly different in patients with tuberculosis (TB) compared with a normal population.
Methods:  Mitochondrial DNA haplogroups M, N, J and K were studied by PCR‐restriction fragment length polymorphism and sequencing. Cases were 54 patients with confirmed smear positive pulmonary TB. Controls were 256 healthy persons.
Results:  There were no statistically significant differences between those with TB and the control group.
Conclusions:  There was no statistically significant association between mtDNA haplogroups and the presence of TB infection.