Hematological, biochemical, respiratory, cardiovascular and electroneurophysiological parameters in African green monkeys (Cercopithecus aethiops sabaeus). Its use in non-clinical toxicological studies

• Published in: Journal of medical primatology Vol. 39; no. 3; pp. 177 - 186
• Main Authors: Casacó, Angel, Beausoleil, Irene, Gonzalez, Bárbara, Luaces, Patricia, León, Avelina, Arteaga, María E., Prado, Pavel, Rodríguez, Valia, Pérez, Aylén, Guevara, Grisel, Bada, Ana M., Ledón, Nuris, Fuentes, Dasha, González, Consuelo, Hernandez, Osvaldo, Orphee, Romy, Blanco, Diuris, García-Osuma, Miriam, Ballester-Labrada, Alcides
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01-06-2010
• Subjects: Animals; Cercopithecus aethiops - physiology; Cercopithecus aethiops sabaeus; Cynomolgus; Disease Models, Animal; Drug Evaluation, Preclinical; Evoked Potentials; Female; Grivet monkeys; Male; Old World monkeys; Primates; safety studies; Toxicity Tests; Vital Signs
• ISSN: 0047-2565; 1600-0684
• DOI: 10.1111/j.1600-0684.2010.00410.x

Background  The purpose of this study is to better characterize the hematological, biochemical, respiratory, cardiovascular and electroneurophysiological parameters in young adult Cercopithecus aethiops sabaeus of both sexes. The rhesus and cynomolgus monkeys are widely used as experimental primate models. However, only few articles have been published testing toxicological effects of pharmaceuticals on African green monkey.
Methods  The present study was carried out with the recompilation of all parameters recorded before the first drug administration in five sub‐chronic or chronic toxicological studies performed on 66 Cercopithecus aethiops sabaeus, born in Cuba.
Results  This study provides hematological, biochemical, respiratory, cardiovascular and electroneurophysiological data for both choosing animals to be included into experiments and monitoring these parameters during the study.
Conclusions  We conclude that this study provides valuable integrated data for determining the health status, including electroneurophysiological parameters, data not previously reported for this species, of the African green monkey.