UnTTrapping the ends： A new player in overcoming protein linked DNA damage

• Published in: Cell research Vol. 20; no. 2; pp. 122 - 123
• Main Authors: Bahmed, Karim, Nitiss, Karin C, Nitiss, John L
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01-02-2010; Nature Publishing Group
• Subjects: 631/337/1427; 631/45/607/1165; Animals; Biomedical and Life Sciences; Cell Biology; DNA Adducts - metabolism; DNA Damage - physiology; DNA Repair - genetics; DNA Repair - physiology; DNA Topoisomerases, Type I - metabolism; DNA拓扑异构酶; DNA损伤; Humans; Life Sciences; Phosphoric Diester Hydrolases - genetics; Phosphoric Diester Hydrolases - metabolism; Phosphoric Diester Hydrolases - physiology; Protein Processing, Post-Translational - physiology; research-highlight; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae Proteins - genetics; Saccharomyces cerevisiae Proteins - metabolism; Saccharomyces cerevisiae Proteins - physiology; Topoisomerase I Inhibitors; 共价键; 反应中间体; 反应机制; 基因组重排; 蛋白质
• ISSN: 1001-0602; 1748-7838
• DOI: 10.1038/cr.2010.17

DNA topoisomerases carry out their reactions by generating transient covalent phosphotyrosine intermediates with DNA [ 1 ]. This reaction mechanism allows these enzymes that need to break DNA to do so in a way that does not induce genome rearrangements or DNA damage responses. However, a variety of agents are able to trap topoisomerases while they are covalently bound to DNA.