The Effect of Erythroid Hyperplasia on Iron Balance

Measurements of erythropoiesis and iron balance were made in eight normal and 32 anemic subjects. The latter consisted of 12 individuals with ineffective erythropoiesis (β-thalassemia/hemoglobin E), 13 subjects with ineffective erythropoiesis and hemolytic anemia (hemoglobin H), and seven subjects w...

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Bibliographic Details
Published in:	Blood Vol. 71; no. 4; pp. 1124 - 1129
Main Authors:	Pootrakul, Pensri, Kitcharoen, Kriengkrai, Yansukon, Pornpan, Wasi, Prawase, Fucharoen, Suthat, Charoenlarp, Preecha, Brittenham, Gary, Pippard, Martin J., Finch, Clement A.
Format:	Journal Article
Language:	English
Published:	Washington, DC Elsevier Inc 01-04-1988 The Americain Society of Hematology
Subjects:	Adolescent Adult Anemia - blood Anemias. Hemoglobinopathies Biological and medical sciences Bone Marrow - pathology Diseases of red blood cells Erythropoiesis Hematologic and hematopoietic diseases Hemoglobin E Hemoglobin H Hemoglobinuria - blood Humans Hyperplasia - blood Iron - blood Male Medical sciences Middle Aged Spherocytosis, Hereditary - blood Thalassemia - blood Erythropoiesis Human Hemoglobinopathy Absorption Overload Anemia Thalassemia Iron Hemopathy
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Summary:	Measurements of erythropoiesis and iron balance were made in eight normal and 32 anemic subjects. The latter consisted of 12 individuals with ineffective erythropoiesis (β-thalassemia/hemoglobin E), 13 subjects with ineffective erythropoiesis and hemolytic anemia (hemoglobin H), and seven subjects with hemolytic anemia (hereditary spherocytosis). A consistent relationship within each group existed between the degree of erythropoiesis and radioiron absorption. Although the effect of erythropoiesis on iron absorption was of similar magnitude in the two thalassemia groups, the effect in hereditary spherocytosis was much less. There was agreement between absorption and ferritin or magnetic susceptibility (SQUID) measurements of iron stores in thalassemia, but in hereditary spherocytosis a discrepancy existed between absorption and ferritin. It is concluded that, although increased erythropoiesis is associated with increased iron absorption, some additional factor associated with red cell breakdown is more directly responsible for the positive iron balance in thalassemia.1988 by Grune & Stratton, Inc.0006-4971/88/7104-0032$3.00/0
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0006-4971 1528-0020
DOI:	10.1182/blood.V71.4.1124.1124