Control of lymphocyte function through CD27–CD70 interactions

• Published in: Seminars in immunology Vol. 10; no. 6; pp. 491 - 499
• Main Authors: Lens, Susanne M.A., Tesselaar, Kiki, van Oers, Marinus H.J., van Lier, René A.W.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-12-1998
• Subjects: Animals; Antigens, CD; B-Lymphocytes - immunology; CD27 Ligand; CD27, CD70, lymphocytes, TNFR–family; Cell Differentiation; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Lymphocyte Activation; Lymphoma, B-Cell; Membrane Proteins - immunology; Membrane Proteins - metabolism; Signal Transduction; T-Lymphocytes - immunology; Tumor Necrosis Factor Receptor Superfamily, Member 7 - immunology; Tumor Necrosis Factor Receptor Superfamily, Member 7 - metabolism; CD27, CD70, lymphocytes, TNFR–family
• ISSN: 1044-5323; 1096-3618
• DOI: 10.1006/smim.1998.0154

In contrast to the expression of other TNFR/TNF family members, expression of CD27 and its ligand CD70 is predominantly confined to lymphocytes. High expression levels of CD27 appear to be dependent on proper ligation of antigen receptors, whereas for the induction of CD70 expression additional (co–stimulatory and/or pro–inflammatory) signals are required. Next to membrane–bound CD27 also a soluble form of CD27 is produced in the course of the immune response. Soluble CD27 (sCD27) is found in body fluids and can be used to monitor local and systemic immune activation. In addition, elevated serum concentrations of sCD27 are found in patients with B cell malignancies and levels of sCD27 strongly correlate with tumor load. Based on functional experiments andin vitroexpression regulation data, we propose that interactions between activated lymphocytesin vivocan result in CD27–CD70 interactions that may regulate the size and function of antigen–primed lymphocyte populations.