Pediatric idiopathic anaphylaxis: Experience with 22 patients

• Published in: Journal of allergy and clinical immunology Vol. 100; no. 3; pp. 320 - 326
• Main Authors: Ditto, Anne Marie, Krasnick, Jane, Greenberger, Paul A., Kelly, Kevin J., McGrath, Kris, Patterson, Roy
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01-09-1997; Elsevier
• Subjects: Adolescent; Adrenergic beta-Agonists - therapeutic use; Adult; airway obstruction; Albuterol - therapeutic use; Anaphylaxis; Anaphylaxis - diagnosis; Anaphylaxis - drug therapy; Anaphylaxis - epidemiology; angioedema; Anti-Inflammatory Agents - therapeutic use; Biological and medical sciences; Child; Delivery of Health Care; Diagnosis, Differential; Female; General aspects; Histamine H1 Antagonists - therapeutic use; Humans; Hydroxyzine - therapeutic use; idiopathic anaphylaxis; Immunopathology; Male; Medical sciences; pediatric; Practice Patterns, Physicians; Prednisone - therapeutic use; urticaria; airway obstruction; angioedema; Anaphylaxis; US-IA; CSD-IA; MIA; urticaria; idiopathic anaphylaxis; IA; pediatric; Human; Respiratory tract; Immunopathology; Skin disease; Angioneurotic edema; Treatment; Respiratory disease; Urticaria; Idiopathic; Child; Obstruction
• ISSN: 0091-6749; 1097-6825
• DOI: 10.1016/S0091-6749(97)70244-6

Idiopathic anaphylaxis in the pediatric population is being increasingly recognized, with symptoms (and therefore classifications) the same as those described in adults. We present a series of 22 patients with special attention to considerations relatively unique to the pediatric population. Prednisone, hydroxyzine, and albuterol were used to control symptoms and induce remission. No deaths occurred during treatment. One adolescent who presented with corticosteroid-dependent idiopathic anaphylaxis was diagnosed with undifferentiated somatoform-idiopathic anaphylaxis. Local physician reluctance to participate in management complicated care for some patients. (J Allergy Clin Immunol 1997;100:320-6.)