Poly (ADP-ribose) polymerase-1 (PARP-1) genetic variants are protective against Parkinson's disease

Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is involved in crucial pathogenic events in Parkinson's disease (PD). We studied the effect of promoter variations of PARP-1 gene on the risk for PD in a case-control association study comprising 146 PD patients and 161 controls from Northern Spa...

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Bibliographic Details
Published in:	Journal of the neurological sciences Vol. 256; no. 1; pp. 68 - 70
Main Authors:	Infante, Jon, Sánchez-Juan, Pascual, Mateo, Ignacio, Rodríguez-Rodríguez, Eloy, Sánchez-Quintana, Coro, Llorca, Javier, Fontalba, Ana, Terrazas, Jesús, Oterino, Agustín, Berciano, José, Combarros, Onofre
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier B.V 15-05-2007 Elsevier Science
Subjects:	Adult Age of Onset Aged Aged, 80 and over Biological and medical sciences Case-Control Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Genetic Variation Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Heterozygote Humans Male Medical sciences Microsatellite Repeats - genetics Middle Aged Nervous system (semeiology, syndromes) Neurology Odds Ratio Oxidative stress Parkinson Disease - genetics Parkinson's disease PARP-1 Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerases - genetics Promoter Regions, Genetic α-synuclein Oxidative stress Parkinson's disease Poly (ADP-ribose) polymerase-1 PARP-1 α-synuclein Nervous system diseases Enzyme Transferases Genetic variant Glycosyltransferases Parkinson disease Cerebral disorder NAD Prevention Central nervous system disease ADP-ribosyltransferase Degenerative disease Pentosyltransferases Extrapyramidal syndrome
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