Poly (ADP-ribose) polymerase-1 (PARP-1) genetic variants are protective against Parkinson's disease

• Published in: Journal of the neurological sciences Vol. 256; no. 1; pp. 68 - 70
• Main Authors: Infante, Jon, Sánchez-Juan, Pascual, Mateo, Ignacio, Rodríguez-Rodríguez, Eloy, Sánchez-Quintana, Coro, Llorca, Javier, Fontalba, Ana, Terrazas, Jesús, Oterino, Agustín, Berciano, José, Combarros, Onofre
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 15-05-2007; Elsevier Science
• Subjects: Adult; Age of Onset; Aged; Aged, 80 and over; Biological and medical sciences; Case-Control Studies; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Female; Genetic Variation; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Heterozygote; Humans; Male; Medical sciences; Microsatellite Repeats - genetics; Middle Aged; Nervous system (semeiology, syndromes); Neurology; Odds Ratio; Oxidative stress; Parkinson Disease - genetics; Parkinson's disease; PARP-1; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases - genetics; Promoter Regions, Genetic; α-synuclein; Oxidative stress; Parkinson's disease; Poly (ADP-ribose) polymerase-1; PARP-1; α-synuclein; Nervous system diseases; Enzyme; Transferases; Genetic variant; Glycosyltransferases; Parkinson disease; Cerebral disorder; NAD; Prevention; Central nervous system disease; ADP-ribosyltransferase; Degenerative disease; Pentosyltransferases; Extrapyramidal syndrome
• ISSN: 0022-510X; 1878-5883
• DOI: 10.1016/j.jns.2007.02.008

Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is involved in crucial pathogenic events in Parkinson's disease (PD). We studied the effect of promoter variations of PARP-1 gene on the risk for PD in a case-control association study comprising 146 PD patients and 161 controls from Northern Spain. Three polymorphisms from the promoter region of PARP-1 gene were analyzed: − 410C/T, − 1672G/A, and a (CA)n microsatellite. A protective effect against PD was found for heterozygosity at (− 410) (OR 0.44) and (CA)n microsatellite (OR 0.53) polymorphisms, and heterozygosity at (− 1672) polymorphism delayed by 4 years on the onset age of PD. Variations in the regulatory region of PARP-1 gene might modify the risk for PD.