Poly (ADP-ribose) polymerase-1 (PARP-1) genetic variants are protective against Parkinson's disease
Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is involved in crucial pathogenic events in Parkinson's disease (PD). We studied the effect of promoter variations of PARP-1 gene on the risk for PD in a case-control association study comprising 146 PD patients and 161 controls from Northern Spa...
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| Published in: | Journal of the neurological sciences Vol. 256; no. 1; pp. 68 - 70 |
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| Main Authors: | , , , , , , , , , , |
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| Abstract | Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is involved in crucial pathogenic events in Parkinson's disease (PD). We studied the effect of promoter variations of PARP-1 gene on the risk for PD in a case-control association study comprising 146 PD patients and 161 controls from Northern Spain. Three polymorphisms from the promoter region of PARP-1 gene were analyzed: − 410C/T, − 1672G/A, and a (CA)n microsatellite. A protective effect against PD was found for heterozygosity at (− 410) (OR 0.44) and (CA)n microsatellite (OR 0.53) polymorphisms, and heterozygosity at (− 1672) polymorphism delayed by 4 years on the onset age of PD. Variations in the regulatory region of PARP-1 gene might modify the risk for PD. |
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| AbstractList | Poly (ADP-ribose) polymerase-1 (PARP-1) is involved in crucial pathogenic events in Parkinson's disease (PD). We studied the effect of promoter variations of PARP-1 gene on the risk for PD in a case-control association study comprising 146 PD patients and 161 controls from Northern Spain. Three polymorphisms from the promoter region of PARP-1 gene were analyzed: -410C/T, -1672G/A, and a (CA)n microsatellite. A protective effect against PD was found for heterozygosity at (-410) (OR 0.44) and (CA)n microsatellite (OR 0.53) polymorphisms, and heterozygosity at (-1672) polymorphism delayed by 4 years on the onset age of PD. Variations in the regulatory region of PARP-1 gene might modify the risk for PD. Poly (ADP-ribose) polymerase-1 (PARP-1) is involved in crucial pathogenic events in Parkinson's disease (PD). We studied the effect of promoter variations of PARP-1 gene on the risk for PD in a case-control association study comprising 146 PD patients and 161 controls from Northern Spain. Three polymorphisms from the promoter region of PARP-1 gene were analyzed: − 410C/T, − 1672G/A, and a (CA)n microsatellite. A protective effect against PD was found for heterozygosity at (− 410) (OR 0.44) and (CA)n microsatellite (OR 0.53) polymorphisms, and heterozygosity at (− 1672) polymorphism delayed by 4 years on the onset age of PD. Variations in the regulatory region of PARP-1 gene might modify the risk for PD. Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is involved in crucial pathogenic events in Parkinson's disease (PD). We studied the effect of promoter variations of PARP-1 gene on the risk for PD in a case-control association study comprising 146 PD patients and 161 controls from Northern Spain. Three polymorphisms from the promoter region of PARP-1 gene were analyzed: − 410C/T, − 1672G/A, and a (CA)n microsatellite. A protective effect against PD was found for heterozygosity at (− 410) (OR 0.44) and (CA)n microsatellite (OR 0.53) polymorphisms, and heterozygosity at (− 1672) polymorphism delayed by 4 years on the onset age of PD. Variations in the regulatory region of PARP-1 gene might modify the risk for PD. |
| Author | Fontalba, Ana Infante, Jon Mateo, Ignacio Terrazas, Jesús Rodríguez-Rodríguez, Eloy Combarros, Onofre Berciano, José Sánchez-Quintana, Coro Sánchez-Juan, Pascual Llorca, Javier Oterino, Agustín |
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| Cites_doi | 10.1097/01.wnr.0000136175.51954.ce 10.1046/j.1471-4159.2003.01684.x 10.1093/nar/20.5.1166 10.1016/S0021-9150(99)00284-1 10.1124/jpet.104.068932 10.1093/hmg/ddi308 10.1007/s00018-004-4508-y 10.1136/pgmj.64.751.345 10.1006/mgme.2000.3015 10.1086/428655 10.1212/01.WNL.0000101721.25345.DC |
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| Keywords | Oxidative stress Parkinson's disease Poly (ADP-ribose) polymerase-1 PARP-1 α-synuclein Nervous system diseases Enzyme Transferases Genetic variant Glycosyltransferases Parkinson disease Cerebral disorder NAD Prevention Central nervous system disease ADP-ribosyltransferase Degenerative disease Pentosyltransferases Extrapyramidal syndrome |
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| References | Chiba-Falek, Kowalak, Smulson, Nussbaum (bib4) 2005; 76 Kato, Morita, Sugiyama, Kurihara, Tsubaki, Nabika (bib9) 2000; 148 Soos, Engelhardt, Siklos, Havas, Majtenyi (bib5) 2004; 15 Comings, MacMurray (bib8) 2000; 71 Gandhi, Wood (bib1) 2005; 14 Koh, Dawson, Dawson (bib2) 2005; 62 Chiarugi, Moskowitz (bib3) 2003; 85 Tan, Chai, Teo, Zhao, Tan, Shen (bib11) 2004; 62 Iwashita, Mihara, Yamazaki, Matsuura, Ishida, Yamamoto (bib10) 2004; 310 Fougerousse, Meloni, Roudaut, Beckmann (bib7) 1992; 20 Gibb (bib6) 1988; 64 Soos (10.1016/j.jns.2007.02.008_bib5) 2004; 15 Iwashita (10.1016/j.jns.2007.02.008_bib10) 2004; 310 Chiarugi (10.1016/j.jns.2007.02.008_bib3) 2003; 85 Kato (10.1016/j.jns.2007.02.008_bib9) 2000; 148 Comings (10.1016/j.jns.2007.02.008_bib8) 2000; 71 Fougerousse (10.1016/j.jns.2007.02.008_bib7) 1992; 20 Gandhi (10.1016/j.jns.2007.02.008_bib1) 2005; 14 Koh (10.1016/j.jns.2007.02.008_bib2) 2005; 62 Tan (10.1016/j.jns.2007.02.008_bib11) 2004; 62 Chiba-Falek (10.1016/j.jns.2007.02.008_bib4) 2005; 76 Gibb (10.1016/j.jns.2007.02.008_bib6) 1988; 64 |
| References_xml | – volume: 62 start-page: 760 year: 2005 ident: bib2 article-title: Poly(ADP-ribosyl)ation regulation of life and death in the nervous system publication-title: Cell Mol Life Sci contributor: fullname: Dawson – volume: 14 start-page: 2749 year: 2005 ident: bib1 article-title: Molecular pathogenesis of Parkinson's disease publication-title: Hum Mol Genet contributor: fullname: Wood – volume: 310 start-page: 1114 year: 2004 ident: bib10 article-title: A new poly(ADP-ribose) polymerase inhibitor, FR261529 [2-(4-chlorophenyl)-5-quinoxalinecarboxamide], ameliorates methamphetamine-induced dopaminergic neurotoxicity in mice publication-title: J Pharmacol Exp Ther contributor: fullname: Yamamoto – volume: 15 start-page: 1715 year: 2004 ident: bib5 article-title: The expression of PARP, NF-kappa B and parvalbumin is increased in Parkinson disease publication-title: NeuroReport contributor: fullname: Majtenyi – volume: 71 start-page: 19 year: 2000 ident: bib8 article-title: Molecular heterosis: a review publication-title: Mol Genet Metab contributor: fullname: MacMurray – volume: 85 start-page: 306 year: 2003 ident: bib3 article-title: Poly(ADP-ribose) polymerase-1 activity promotes NF-kappaB-driven transcription and microglial activation: implication for neurodegenerative disorders publication-title: J Neurochem contributor: fullname: Moskowitz – volume: 20 start-page: 1166 year: 1992 ident: bib7 article-title: Dinucleotide repeat polymorphism at the human poly (ADP-ribose) polymerase gene (PPOL)q publication-title: Nucleic Acids Res contributor: fullname: Beckmann – volume: 62 start-page: 128 year: 2004 ident: bib11 article-title: Alpha-synuclein haplotypes implicated in risk of Parkinson's disease publication-title: Neurology contributor: fullname: Shen – volume: 64 start-page: 345 year: 1988 ident: bib6 article-title: Accuracy in the clinical diagnosis of parkinsonian syndromes publication-title: Postgrad Med J contributor: fullname: Gibb – volume: 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| Snippet | Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is involved in crucial pathogenic events in Parkinson's disease (PD). We studied the effect of promoter... Poly (ADP-ribose) polymerase-1 (PARP-1) is involved in crucial pathogenic events in Parkinson's disease (PD). We studied the effect of promoter variations of... |
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| SubjectTerms | Adult Age of Onset Aged Aged, 80 and over Biological and medical sciences Case-Control Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Genetic Variation Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Heterozygote Humans Male Medical sciences Microsatellite Repeats - genetics Middle Aged Nervous system (semeiology, syndromes) Neurology Odds Ratio Oxidative stress Parkinson Disease - genetics Parkinson's disease PARP-1 Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerases - genetics Promoter Regions, Genetic α-synuclein |
| Title | Poly (ADP-ribose) polymerase-1 (PARP-1) genetic variants are protective against Parkinson's disease |
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